Influence of hereditary and acquired thrombophilia on the outcomes of assisted reproductive technology programs

Kraevaya E.E., Dolgushina N.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russian
By analyzing the data available in the literature, the authors estimated the influence of hereditary and acquired thrombophilia on the effectiveness of assisted reproductive technology (ART) programs and the efficacy of low-molecular-weight heparins (LMWH) to improve the outcomes of ART programs. The review included data from foreign and Russian articles published over the past 10 years, which were found in the databases of Pubmed, Elsevier, and Cochrane Library on this topic. The role of hereditary and acquired thrombophilia in the effectiveness of ART programs and the use of LMWH to improve the outcomes of ART programs are a debatable issue and require further investigations.


assisted reproductive technologies
hereditary thrombophilia
antiphospholipid syndrome
antiphospholipid antibodies
low-molecular-weight heparins


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Received 22.02.2019

Accepted 19.04.2019

About the Authors

Kraevaya Elizaveta Evgenievna, junior researcher of department of assisted reproductive technology in treating sterilityV.I. Kulakov NMRC OGP, Ministry of Healthcare
of the Russian Federation Tel. +7 (495) 438-25-01.E-mail: 4 Oparin str, 117997, Moscow, Russia
Dolgushina Nataliya Vitalievna, M.D., M.P.H., Head of R&D Department, V.I. Kulakov NMRC OGP, Ministry of Healthcare of the Russian Federation
Tel: +7 (495) 438-49-77.E-mail:
4 Oparin str, 117997, Moscow, Russia

For citation: Kraevaya E.E., Dolgushina N.V. Influence of hereditary and acquired thrombophilia on the outcomes of assisted reproductive technology programs.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 8:20-25 (in Russian).

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