Impact of the embryological stage on the effectiveness of assisted reproductive technology programs with frozen-thawed embryo transfer
Purpose of the study. To investigate the impact of the embryological stage on the effectiveness of assisted reproductive technologies (ART) programs for frozen embryo transfer (FET ).Petrosyan Ya.A., Syrkasheva A.G., Makarova N.P.
Materials and methods. 288 couples were treated for infertility with the use of ART program for FET. The patients were stratified into two groups depending on the onset of pregnancy: group 1 (pregnancy +, n=92), group 2 (pregnancy -, n=196). Then the impact of the embryological stage on the effectiveness of ART programs was assessed.
Results. The clinical pregnancy rate was 31,9% (n=92). The assessment of clinical and anamnestic characteristics did not reveal statistically significant differences in the groups. In both groups the characteristics of the clinical phase of preparing the endometrium were comparable. In vitro fertilization (IFV), an excellent morphology of the thawed embryos, as well as the blastocyst vitrification on day 5 of cultivation had a positive effect on pregnancy rates. Assisted hatching and embryo transfer in a hyaluronic acid-enriched culture medium had no effect on frequency of clinical pregnancies in the total number of patients.
Conclusion. The following factors may be considered as the main predictors of pregnancy in frozen embryo transfer: embryo quality during thawing, vitrification of embryos on day 5 of cultivation, and in vitro fertilization (IVF).
Keywords
assisted reproductive technologies
embryos
hatching
pregnancy
embryo thawing
frozen embryos
cryotransfer
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Received 31.01.2020
Accepted 07.02.2020
About the Authors
Anastasia G. Syrkasheva, M.D., Ph.D., Senior Researcher of B.V. Blokhin IVF Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of RussiaAddress: Akademica Oparina, 4, 117997, Moscow, Russia
E-mail: a_syrkasheva@oparina4.ru
Yana A. Petrosyan, PhD student of B.V. Blokhin IVF Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia
Address: Akademica Oparina, 4, 117997, Moscow, Russia
E-mail: Yana_petrosyan86@mail.ru
Natalia P. Makarova, PhD, senior researcher of B.V. Blokhin IVF Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia
Address: Akademica Oparina, 4, 117997, Moscow, Russia
E-mail: np_makarova@oparina4.ru
For citation: Syrkasheva A.G., Petrosyan Ya.A., Makarova N.P. Impact of the embryological stage on the effectiveness of assisted reproductive technology programs with frozen-thawed embryo transfer.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 4: 127-132. (In Russian).
https://dx.doi.org/10.18565/aig.2020.4.127-132
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