Ultrasound diagnosis in the evaluation of parasternal lymph nodes in patients with breast cancer
Snitkin V.M., Khakurinova N.D., Sholokhov V.N., Berdnikov S.N., Makhotina M.S., Valiev R.K., Sinyukova G.T., Gus A.I.
Objective. To enhance the effectiveness of diagnosing metastatic parasternal lymph nodes in patients with breast cancer (BC).
Subjects and methods. The investigation enrolled 52 patients treated at the N.N. Blokhin National Medical Research Center of Oncology and diagnosed with BC. All patients underwent ultrasound examination (USE) of the breast and parasternal lymph nodes.
Results. A total of 28 enlarged lymph nodes were detected. Enlarged parasternal lymph nodes were diagnosed in 19 (37%) patients; 7 (13.5%) patients had lymph nodes visualized in two or more intercostal spaces. There were 6 (21.4%) lymph nodes with signs of the specific lesion; 5 (9.6%) with metastatic parasternal lymph nodes; the stage of the disease was adjusted to higher one (IIIA) due to damage to the parasternal lymphatic collector. Analysis of estrogen and progesterone receptors (ER and PR) and HER2 showed that there was a basal-like, triple negative subtype of BC, ER-0, PR-0, HER2-0, Ki67> 80% in all cases of metastatic lesion.
Conclusion. USE in evaluating the parasternal lymph nodes can be a useful tool for identifying metastatic lymph nodes.
Keywords
ultrasound diagnosis
breast cancer
parasternal lymph nodes
parasternal region
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Received 08.04.019
Accepted 19.04.2019
About the Authors
Vyacheslav M. Snitkin, post-graduate student of the Department of ultrasound diagnostics of the research Institute of clinical and experimental radiology Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO)Tel. + 7 (499)324-98-95 E-mail: snitkinvm@yandex.ru. 115478 Moscow, Kashirskoye highway, d. 23.
Nafset D. Khakurinova, post-graduate student of the Department of radiosurgery research Institute of clinical Oncology Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO)
Tel. +7 (499)324-98-95 E-mail: nafset2701@mail.ru. 115478 Moscow, Kashirskoye highway, d. 23.
Vladimir N. Sholokhov, Doctor of Medical Sciences, Professor, leading researcher of the Department of ultrasound diagnostics of the research Institute of clinical and experimental radiology Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO). Tel. + 7 (499)324-98-95 E-mail: vnshell@mail.ru. 115478 Moscow, Kashirskoye highway, d. 23.
Galina T. Sinyukova, Doctor of Medical Sciences, Professor, head of the Department of ultrasound diagnostics of the research Institute of clinical and experimental radiology Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO). Tel. +7 (499)324-98-95 E-mail: profsinukova@mail.ru. 115478 Moscow, Kashirskoye highway, d. 23.
Sergey N. Berdnikov, PhD, researcher of the Department of ultrasound diagnostics of the research Institute of clinical and experimental radiology Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO)
Tel. +7 (499)324-98-95 E-mail: berdnikov_sn@mail.ru. 115478 Moscow, Kashirskoye highway, d. 23.
Mariya S. Mahotina, PhD, physician of the Department of ultrasound diagnostics of the research Institute of clinical and experimental radiology Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO)
Tel. +7 (499)324-98-95 E-mail: berdnikov_sn@mail.ru. 15478 Moscow, Kashirskoye highway, d. 23.
Ramiz K. Valiev, PhD., head of the Department of radiosurgery of the research Institute of clinical Oncology. N. N. Trapeznikova Federal State Budgetary Institution
«N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO)
Tel. +7 (499)324-98-95 E-mail: info@ronc.ru. 115478 Moscow, Kashirskoye highway, d. 23.
Alexander I.Gus, , MD, Head of Functional Diagnostics at the Department of Diagnostic Imaging, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. E-mail: a_gus@oparina4.ru; eLibrary SPIN. code: 1464-2786.
17997, Russia, Moscow, Ac. Oparina str. 4.
For citation: Snitkin V.M., Khakurinova N.D., Sholokhov V.N., Berdnikov S.N., Makhotina M.S., Valiev R.K., Sinyukova G.T., Gus A.I. Ultrasound diagnosis in the evaluation of parasternal lymph nodes in patients with breast cancer.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 9:148-52 (In Russian).
https://dx.doi.org/10.18565/aig.2019.9.148-152
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