Portal vein thrombosis while taking a combined oral contraceptive after experienced coronavirus infection
Background: Contraceptives are an important component of women’s reproductive health care, as they not only reduce the number of unwanted pregnancies, but also improve reproductive function. However, oral contraceptives are known to increase the risk of venous thromboembolism. This risk is increased by infection with the COVID-19 virus that predisposes patients to both venous and arterial thrombosis as a result of excessive inflammation, platelet activation, aggravated endothelial dysfunction, and congestive events. If these patients have hereditary thrombophilia, the risk of venous thromboembolism becomes fatal.Shklyaev A.E., Fatkhieva A.R., Bessonov A.G., Meleshkina M.V., Zykov S.Yu.
Case report: The paper describes a clinical case of a patient with total portal vein thrombosis, who have been taking oral contraceptives for a long time and recovering from the novel coronavirus infection. Studying the blood coagulation system and folate cycle genes, by using PCR, has revealed a gene mutation in the plasminogen activator inhibitor (serpine). The authors demonstrate the data of spiral computed tomography of the abdominal organs, as well as changes in laboratory parameters.
Conclusion: A balanced approach is required when prescribing combined oral contraceptives during the
COVID-19 pandemic, especially in women with prothrombotic mutations.
Authors’ contributions: Shklyaev A.E., Fatkhieva A.R., Bessonov A.G., Meleshkina M.V., Zykov S.Yu. – material collection and processing; Shklyaev A.E., Fatkhieva A.R. – writing the text; Shklyaev A.E. – editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: Funding was provided by the authors.
Patient Consent for Publication: The patient has signed an informed consent form to the publication of her data.
For citation: Shklyaev A.E., Fatkhieva A.R., Bessonov A.G., Meleshkina M.V., Zykov S.Yu. Portal vein thrombosis while taking a combined oral contraceptive after experienced coronavirus infection.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (2): 165-170 (in Russian)
https://dx.doi.org/10.18565/aig.2023.5
Keywords
portal vein thrombosis
oral contraceptives
gene polymorphism of the hemostatic system
novel coronavirus infection
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Received 12.01.2022
Accepted 26.01.2023
About the Authors
Alexey E. Shklyaev, Dr. Med. Sci., Professor, Professor at the Department of Faculty Therapy with courses of endocrinology and hematology, Izhevsk State Medical Academy, Ministry of Health of Russia, +7(3412)52-62-01, shklyaevaleksey@gmail.com, https://orcid.org/0000-0003-4479-508X, 426056, Russia, Izhevsk, Kommunarov str., 281.Alina R. Fatkhieva, student, Izhevsk State Medical Academy, Ministry of Health of Russia, +7(922)509-42-66, alifathi98@mail.ru,
426056, Russia, Izhevsk, Kommunarov str., 281.
Alexey G. Bessonov, PhD, Head of the Gastroenterology Department, First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic, +7(3412)46-52-92, besson_alex@mail.ru, Russia, 426039, Izhevsk, Votkinskoe highway str., 57.
Maria V. Meleshkina, gastroenterologist, First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic, +7(3412)46-52-92,
426039, Russia, Izhevsk, Votkinskoe highway str., 57.
Sergey Yu. Zykov, radiologist, First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic, +7(904)314-67-56, sergeyzykov1977@gmail.com,
426039, Russia, Izhevsk, Votkinskoe highway str., 57.
Corresponding author: Alina R. Fatkhieva, alifathi98@mail.ru
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