Comparison of the efficiency of drug and mechanical methods for pre-induction cervical preparation
Objective. To compare and investigate the efficacy of miropristone, luminaria, and Foley catheter for the pre-induction cervical preparation in full-term pregnancy.Bakleicheva M.O., Bespalova O.N., Bolotskikh V.M., Kogan I.Yu.
Material and methods. The patients were divided into 3 groups: 1) miropristone (n = 49); 2) laminaria sticks (n = 45); 3) Foley catheter (n = 48). The inclusion criteria were full-term at >37 weeks’ gestational age; degree of cervical ripening with a Bishop score of 3-5; singleton pregnancy; cephalic presentation; the whole amniotic fluid sac.
Results. The patients of 3 groups did not differ statistically in age, body mass index, and gestational age. Miropristone showed its efficacy in inducing cervical ripening with labor activation at full-term gestation without maternal and fetal complications. The use of this drug promotes the spontaneous development of labor, reducing the frequency of labor induction and optimizing the duration of parturition. Miropristone is effective in preparing the maternal passages, irrespective of parity. Its use significantly reduces the frequency of cesarean delivery, excluding the reason for the lack of biological readiness of the maternal passages.
Conclusion. Unlike laminaria and Foley catheter, miropristone reduces the total time to prepare the maternal passages and is suitable for both pre-induction and induction of labor.
Keywords
miropristone
laminaria
Foley catheter
preinduction cervical preparation for childbirth
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Received 06.04.2018
Accepted 20.04.2018
About the Authors
Margarita O. Bakleicheva, resident doctor of D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology.199034, Russia, Saint-Petersburg, Mendeleyevskaya Line 3. Tel.: +79112736538. E-mail: bakleicheva@gmail.com
Olesya N. Bespalova, PhD, Deputy Director for Research of D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology.
199034, Russia, Saint-Petersburg, Mendeleyevskaya Line 3. E-mail: shiggerra@mail.ru
Vyacheslav M. Bolotskikh, PhD, Deputy director for medical work of D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology; Saint-Petersburg State University. 199034, Russia, Saint-Petersburg, Universitetskaya Emb. 13B. E-mail: docgin@yandex.ru
Igor Yu. Kogan, Corresponding Member of RAS, PhD, professor, director of D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology.
199034, Russia, Saint-Petersburg, Mendeleyevskaya Line 3. E-mail: ikogan@mail.ru
For citations: Bakleicheva M.O., Bespalova O.N., Bolotskikh V.M., Kogan I.Yu. Comparison of the efficiency of drug and mechanical methods for pre-induction cervical preparation. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (6): 100-6. (in Russian)
https://dx.doi.org/10.18565/aig.2018.6.100-106
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