Spontaneous ovarian hyperstimulation syndrome
Background. The genetic determinants of ovarian hyperstimulation syndrome (OHSS) are relevant due to the fact that the prediction of this complication by routine clinical and laboratory markers is not always objective. The emergence of spontaneous forms of the OHSS is associated just with the peculiarities of the genotype.Strelchenko D.A., Perminova S.G., Donnikov A.E., Korneeva I.E., Abubakirov A.N.
Description. The paper presents a clinical case of OHSS in a patient with spontaneous pregnancy and shows the relationship of this condition to the OHSS risk genotypes identified in the study of genetic features of the development and course of OHSS in ART programs.
Conclusion. The development of OHSS in spontaneous pregnancy and the detection of the genotype characteristics of this condition in this patient emphasize the contribution of genetics to the development of this complication and the relevance of searching for new markers to personalize ART programs. Genetic testing is a highly specific technique that can minimize the risks associated with the development of OHSS.
Keywords
spontaneous ovarian hyperstimulation syndrome (sOHSS)
molecular genetic predictors
gene polymorphism
References
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Received 28.05.2018
Accepted 22.06.2018
About the Authors
Strelchenko, Daria A., junior researcher of the Department of Preservation and Restoration of Reproductive Function, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation.117997, Russia, Moscow, Ac. Oparina str. 4.Tel.: +79099832944. E-mail: da_strelchenko@mail.ru
Perminova, Svetlana G., MD, leading researcher of the Department of Preservation and Recovery of Reproductive, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79162021687. E-mail: perisvet@list.ru
Donnikov, Andrei E., PhD, head of the Laboratory of Molecular Genetic Methods, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: a_donnikov@oparina4.ru
Korneeva, Irina E., MD, Department of Preservation and Recovery of Reproductive Functions, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel: +79035939748. E-mail: irina.korneeva@inbox.ru
Abubakirov, Aidar N., PhD, head of the Department of Preservation and Restoration of Reproductive Function, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel: +74954382622. E-mail: nondoc555@yahoo.com
For citations: Strelchenko D.A., Perminova S.G., Donnikov A.E., Korneeva I.E., Abubakirov A.N. Spontaneous ovarian hyperstimulation syndrome. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (1): 166-70. (in Russian)
http://dx.doi.org/10.18565/aig.2019.1.166-170