Spontaneous ovarian hyperstimulation syndrome

Strelchenko D.A., Perminova S.G., Donnikov A.E., Korneeva I.E., Abubakirov A.N.

1 Academician V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow 2 OOO «DNA Technology», Moscow
Background. The genetic determinants of ovarian hyperstimulation syndrome (OHSS) are relevant due to the fact that the prediction of this complication by routine clinical and laboratory markers is not always objective. The emergence of spontaneous forms of the OHSS is associated just with the peculiarities of the genotype.
Description. The paper presents a clinical case of OHSS in a patient with spontaneous pregnancy and shows the relationship of this condition to the OHSS risk genotypes identified in the study of genetic features of the development and course of OHSS in ART programs.
Conclusion. The development of OHSS in spontaneous pregnancy and the detection of the genotype characteristics of this condition in this patient emphasize the contribution of genetics to the development of this complication and the relevance of searching for new markers to personalize ART programs. Genetic testing is a highly specific technique that can minimize the risks associated with the development of OHSS.

Keywords

spontaneous ovarian hyperstimulation syndrome (sOHSS)
molecular genetic predictors
gene polymorphism

References

  1. Корнеева И.Е., Перминова С.Г., Пырегов А.В., Павлович С.В., Смольникова В.Ю., Мишиева Н.Г., Юренева С.В., Сароян Т.Т., Краснова Н.А., Ермакова Е.И. Диагностика, лечение и профилактика синдрома гиперстимуляции яичников. Учебно-методическое пособие. М.: ГЭОТАР-Медиа; 2016. [Korneeva I.E., Perminova S.G., Pyregov A.V., Pavlovich S.V., Smolnikova V.Yu.,Mishieva N.G., Yureneva S.V., Saroyan T.T., Krasnova N .A., Ermakova EI Diagnosis, treatment and prevention of ovarian hyperstimulation syndrome. Teaching manual. M .: GEOTAR-Media; 2016. (in Russian)]
  2. Vasseur C., Rodien P., Beau I., Desroches A., Gerard C., de Poncheville L. A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome. N. Engl. J. Med. 2003; 349(8): 753-9.
  3. Dieterich M., Bolz M., Reimer T., Costagliola S., Gerber B. Two different entities of spontaneous ovarian hyperstimulation in a woman with FSH receptor mutation. Reprod. Biomed. Online. 2010; 20(6): 751-8.
  4. Osaikhuwuomwan J.A., Osemwenkha A.P. Ovarian hyperstimulation syndrome in a spontaneous pregnancy: A potential for missed-diagnosis. Niger. Med. J. 2016; 57(1): 74-6.
  5. Edwards-Silva R.N., Han C.S., Hoang Y., Kao L.C. Spontaneous ovarian hyperstimulation in a naturally conceived pregnancy with uncontrolled hypothyroidism. Obstet. Gynecol. 2008; 111(2, Pt 2): 498-501.
  6. Borna S., Nasery A. Spontaneous ovarian hyperstimulation in a pregnant woman with hypothyroidism. Fertil. Steril. 2007; 88(3): 705. e701-3.
  7. Dey A.K., Dubey A., Mittal K., Kale S. Spontaneous ovarian hyperstimulation syndrome - understanding the dilemma. Gynecol. Endocrinol. 2015; 31(8): 587-9.
  8. Cabar F.R. Ovarian hyperstimulation syndrome in a spontaneous singleton pregnancy. Einstein (Sao Paulo); 26 May 2016.
  9. Kim M.K., Won H.J., Shim S.H., Cha D.H., Yoon T.K. Spontaneous ovarian hyperstimulation syndrome following a thawed embryo transfer cycle. Clin. Exp. Reprod. Med. 2014; 41(3): 140-5.
  10. De Leener A., Montanelli L., Van Durme J., Chae H., Smits G., Vassart G., Costagliola S. Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology. J. Clin. Endocrinol. Metab. 2006; 91(2): 555-62.
  11. Стрельченко Д.А., Перминова С.Г., Донников А.Е., Кадочникова В.В., Абрамов Д.Д., Корнеева И.Е., Сароян Т.Т., Абубакиров А.Н. Молекулярно-генетические предикторы развития синдрома гиперстимуляции яичников в программе экстракорпорального оплодотворения. Акушерство и гинекология. 2016; 4: 56-63. [Strelchenko D.A., Perminova S.G., Donnikov A.E.,Kadochnikova V.V., Abramov D.D., Korneeva I.E., Saroyan T.T., Abubakirov A.N. Molecular genetic predictors of ovarian hyperstimulation syndrome development in an in vitro fertilization program. Obstetrics and gynecology. 2016; 4: 56-63. (in Russian)]
  12. Владимирова И.В., Калинина Е.А., Донников А.Е. Молекулярно-генетические маркеры как прогностические факторы овариального ответа в программах ВРТ. Акушерство и гинекология. 2014; 3: 16-20. [Vladimirova I.V., Kalinina E.A., Donnikov A.E. Molecular genetic markers as prognostic factors of the ovarian response in ART programs. Obstetrics and gynecology. 2014; 3: 16-20. (in Russian)]
  13. Taher B.M., Ghariabeh R.A., Jarrah N.S., Hadidy A.M., Radaideh A.M., Ajlouni K.M. Spontaneous ovarian hyperstimulation syndrome caused by hypothyroidism in an adult. Eur. J. Obstet. Gynecol. Reprod. Biol. 2004; 112(1): 107-9.
  14. Фадеев В.В., Перминова С.Г., Назаренко Т.А., Корнеева И.Е., Мельниченко Г.А., Дедов И.И. Заболевания щитовидной железы и репродуктивная функция женщины. Пособие для врачей. М.; 2009. [Fadeev V.V., Perminova S.G., Nazarenko T.A., Korneeva I.E., Melnichenko G.A., Dedov I.I. Diseases of the thyroid gland and the reproductive function of women. Manual for doctors. M .; 2009. (in Russian)]
  15. Soares S.R. Etiology of OHSS and use of dopamine agonists. Fertil. Steril. 2012; 97(3): 517-22.
  16. Rodewald M., Herr D., Duncan W.C., Fraser H.M., Hack G., Konrad R. et al. Molecular mechanisms of ovarian hyperstimulation syndrome: paracrine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability. Hum. Reprod. 2009; 24(5): 1191-9.
  17. Hanevik H.I., Hilmarsen H.T., Skjelbred C.F., Tanbo T., Kahn J.A. Increased risk of ovarian hyperstimulation syndrome following controlled ovarian hyperstimulation in patients with vascular endothelial growth factor +405 cc genotype. Gynecol. Endocrinol. 2012; 28(11): 845-9.
  18. O’Brien T.J., Kalmin M.M., Harralson A.F., Clark A.M., Gindoff I., Simmens S.J. et al. Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. Reprod. Biol. Endocrinol. 2013; 11: 71.
  19. Coviello A.D., Haring R., Wellons M., Vaidya D., Lehtimaki T., Keildson S. et al. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet. 2012; 8(7): e1002805.
  20. Ayvaz O.U., Ekmekci A., Baltaci V., Onen H.I., Unsal E. Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertility. J. Assist. Reprod. Genet. 2009; 26(9-10): 503-10.
  21. de Mattos C.S., Trevisan C.M., Peluso C., Adami F., Cordts E.B., Christofolini D.M. et al. ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women. J. Ovarian Res. 2014; 7: 114.

Received 28.05.2018

Accepted 22.06.2018

About the Authors

Strelchenko, Daria A., junior researcher of the Department of Preservation and Restoration of Reproductive Function, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4.Tel.: +79099832944. E-mail: da_strelchenko@mail.ru
Perminova, Svetlana G., MD, leading researcher of the Department of Preservation and Recovery of Reproductive, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79162021687. E-mail: perisvet@list.ru
Donnikov, Andrei E., PhD, head of the Laboratory of Molecular Genetic Methods, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: a_donnikov@oparina4.ru
Korneeva, Irina E., MD, Department of Preservation and Recovery of Reproductive Functions, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel: +79035939748. E-mail: irina.korneeva@inbox.ru
Abubakirov, Aidar N., PhD, head of the Department of Preservation and Restoration of Reproductive Function, National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel: +74954382622. E-mail: nondoc555@yahoo.com

For citations: Strelchenko D.A., Perminova S.G., Donnikov A.E., Korneeva I.E., Abubakirov A.N. Spontaneous ovarian hyperstimulation syndrome. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (1): 166-70. (in Russian)
http://dx.doi.org/10.18565/aig.2019.1.166-170

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.