Modern possibilities for complex therapy of infectious and inflammatory diseases of the cervix and vagina in the practice of an obstetrician-gynecologist.
Bayramova G.R., Andreev A.O., Kecherukova I.B.
The effective treatment and prevention of recurrence of infectious and inflammatory diseases of the cervix and vagina require careful diagnosis and therapy.
Objective: To evaluate the efficacy of peptide-protein complex containing natural peptides and cytokines in the therapy of cervicitis and vaginitis with mixed etiology.
Materials and methods: This study presents a comparative analysis of the results of therapy for 80 patients diagnosed with cervicitis, which was associated with bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and human papillomavirus (HPV). The patients were divided into two groups: group 1 (n=40) received standard therapy in combination with a complex of natural peptides and cytokines (the Superlymph drug, suppositories administered rectally at a dose of 25 IU twice a day for 20 days); group 2 (n=40) received standard therapy without peptide-protein complex. The effectiveness of the treatment was evaluated on the basis of the patient’s complaints, clinical picture of the disease and the results of laboratory tests at one and three months after the end of therapy.
Results: After one month of treatment, 2/40 (5%) patients in group 1 continued to experience pathologic discharge from the genital tract. In group 2, clinical manifestations of the disease in the form of moderate genital discharge, itching and vaginal discomfort were noted in 6/40 (15%) women. HPV DNA testing showed the absence of HPV in 57.5% of patients in group 1 and in 27.5% of women in group 2. The median viral load was calculated again: it was 3.9 lg (3.3; 4.5) in group 1 and 4.4 lg (3.8; 4.9) in group 2. After three months, no recurrence of the disease was detected in group 1; however, 4/40 (10%) women in group 2 were diagnosed with recurrent episodes of cervicitis which was associated with BV and VVC in two cases, BV in one case, and aerobic vaginitis in one case.
Conclusion: Due to the frequent recurrence of the disease resulting from inadequate efficacy of therapy, it is extremely important to prescribe treatment that targets each etiologic agent of the disease. The use of the medication based on natural peptides and cytokines showed high efficacy in the complex treatment of cervicitis and vaginitis.
Authors’ contributions: Bayramova G.R. – developing the design and concept of the study, writing the text, editing the article; Andreev A.O. – searching and processing literature sources, writing the text; Kecherukova I.B. – searching and processing literature sources.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study is sponsored by the company Biotechpharm.
Ethical Approval: The study was approved by the Ethical Review Board of the Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Bayramova G.R., Andreev A.O., Kecherukova I.B. Modern possibilities for complex therapy of infectious and inflammatory diseases of the cervix and vagina in the practice of an obstetrician-gynecologist.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (8): 127-132 (in Russian)
https://dx.doi.org/10.18565/aig.2024.190
Keywords
infectious and inflammatory diseases of the cervix and vagina
cervicitis
vaginitis
complex therapy
peptide-protein complex of natural peptides and cytokines
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Received 01.08.2024
Accepted 12.08.2024
About the Authors
Guldana R. Bayramova, Dr. Med. Sci., Merited Doctor of the Russian Federation, Professor at the Department of Obstetrics and Gynecology of the Department of Professional Education, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, Clinical Care Supervisor at the Research and Outpatient Department, V.I. KulakovNMRC for OG&P, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin, 4 +7(926)660-48-77, bayramova@mail.ru, https://orcid.org/0000-0003-4826-661X
Alexander O. Andreev, obstetrician gynecologist at the Research and Outpatient Department, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia,
117997, Russia, Moscow, Ac. Oparin str., 4, +7(903)613-00-26, sasha.grash2010@yandex.ru, https://orcid.org/0000-0002-9835-440X
Izabel B. Kecherukova, 6th year student, Pirogov RNRMU, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanov str., 1, +7(928)028-79-69,
kecherukovaib@gmal.com, https://orcid.org/0000-0002-6650-6456
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