Current ideas about the specific features of vaginal microbiocenosis in HIV-positive women of reproductive age

Maryanyan A.Yu., Slepchenko V.V., Rashidova M.A., Podkameneva T.V., Kolesnikova L.I.

1) Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia; 2) Irkutsk State Medical University, Ministry of Health of Russia, Irkutsk, Russia; 3) Irkutsk State Medical Academy of Postgraduate Education, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Irkutsk, Russia
To analyze data from investigations dealing with the impact of HIV infection on vaginal microbiocenosis; to study the differences of dysbiotic disorders in seronegative and seropositive women; to evaluate the impact of the vaginal microbiota on the pre-exposure prophylaxis of HIV. The results of Russian and foreign studies of the microbiota in HIV-positive women, which had been published in international databases, were analyzed. The presented data analysis suggests that dysbiotic disorders are significantly more common in HIV-infected patients. The atypical clinical presentation of vaginal microbiocenotic changes has been also noted to prevail. There is a relationship between vaginal microbiocenosis in HIV-positive women and systemic immunity indicators and CD4+ cell levels.
There is a need for additional studies of the qualitative and quantitative composition of the microflora in HIV-positive women, by evaluating the impact of the vaginal microbiota and the influence of possible factors on the change in the concentration of antiretroviral drugs.

Keywords

vaginal microbiocenosis
HIV infection
dysbiotic disorders

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Received 17.04.2019

Accepted 19.04.2019

About the Authors

Anait Yu Marianian., MD, PhD, Head of the Laboratory of Socially Important Problems of Reproductology, Leading Researcher; Associate Professor of the Department of Obstetrics and Gynecology of the ISMAPGE - Branch Campus of the FSBEI FPE RMACPE MOH Russian. Tel.: +7 (3952)207636; +7(914)0147065.
E-mail: anait_24@mail.ru; iphr@sbamsr.irk.ru ORCID: 0000-0002-9544-2172
Address: 664003, Russia, Irkutsk, Timiryazev str. 16.
Valeria V. Slepchenko , resident of the Department of Obstetrics and Gynecology, Irkutsk State Medical University, Ministry of Health of the Russian Federation.
Tel.: +7(908)6424540. E-mail: slepchenko.vv@mail.ru ORCID: 0000-0003-2807-4768
Address: 664003, Russia, Irkutsk, Krasnogo Vostania str. 1.
Maria A. Rashidova, PhD, Scientific Researcher, Laboratory of Physiology and Pathology of the endocrine system Centre for Family Health and Human Reproduction Problems. Tel.: +7 (3952)207636; +7(924)7018727. E-mail: rashidovama@mail.ru ORCID: 0000-0003-4730-5154
Address: 664003, Russia, Irkutsk, Timiryazeva str. 16.
Tatyana V. Podkameneva, PhD, assistant of the Department of Obstetrics and Gynecology with a course of gynecology of children and adolescents, Irkutsk State Medical University, Ministry of Health of the Russian Federation. Tel.: +7(924)8325060. E-mail: t.podkameneva@mail.ru ORCID: 0000-0002-4909-4680
Address: 664003, Russia, Irkutsk, Krasnogo Vostania str. 1.
Lyubov I. Kolesnikova, academician of RAS, Scientific Supervisor, Scientific Centre for Family Health and Human Reproduction Problems.
Tel.: +7 (3952)207636. E-mail: iphr@sbamsr.irk.ru ORCID: 0000-0003-3354-2992
Address: 664003, Russia, Irkutsk, Timiryazeva str. 16.

For citation: Maryanyan A.Yu., Slepchenko V.V., Rashidova M.A., Podkameneva T.V., Kolesnikova L.I. Current ideas about the specific features of vaginal microbiocenosis in HIV-positive women of reproductive age.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 12: 12-17. (In Russian).
https://dx.doi.org/10.18565/aig.2019.12.12-17

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