Combined use of antibiotics and probiotics as a way to enhance the efficiency of treatment for genital infections
Objective. To evaluate the efficiency of combined use of antibiotics and probiotics in patients with bacterial vaginosis and trichomoniasis.Sgibnev A.V., Kremleva E.A., Shchetinina Yu.S., Cherkasova Yu.I.
Material and methods. Based on subjective and objective (pH and redox potential, the number of lactobacilli, T. vaginalis, A. vaginae, G. vaginalis, Amsel, Nugent and Hay-Ison scoring criteria) parameters, the investigators evaluated the efficiency of combined use of oral metronidazole and the intravaginal probiotic lactoginal. The control group received traditional therapy.
Results. The use of probiotics in combination with metronidazole led to a more intense normalization of the physicochemical and microbiological parameters of the biotope. The efficiency of this therapy regimen was 80%, while that of traditional therapy was 20%.
Conclusion. Potentiation of the antimicrobial activity of antibiotics by probiotics has been confirmed in vivo. Probiotics that potentiate the activity of antibiotics are able to replenish the function of the normal microflora during antibiotic therapy. A question is raised as to the need for a new indication for the use of probiotics – to improve the efficiency of antibiotic therapy.
Keywords
Lactobacillus casei subsp. rhamnosus LCR35
antibiotic therapy
bacterial vaginosis
lactobacilli
metronidazole
probiotics
trichomoniasis
Supplementary Materials
- Fig. 1. Subjective assessment by patients of their condition (according to the data of self-observation diaries)
- Fig. 2. Characteristics of the microbiological state of the vagina of patients of Groups I and II: frequency of T. vaginalis (A), number of Lactobacillus spp. (B), G. vaginalis (С) and A. vaginae (D)
- Fig. 3. Characteristics of the state of microecology of the vagina of patients of groups I and II: pH (A), oxidation-reduction potential (B), criteria Nugent (С) and Hay-Ison (D)
References
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Received 16.02.2018
Accepted 02.03.2018
About the Authors
Sgibnev Andrey, doctor of Biology, associate professor, leading researcher, Laboratory for the study of the mechanisms of formation microbiocenoses of humans,Institute of Cellular and Intracellular Symbiosis, Ural Branch, Russian Academy of Sciences.
460000, Russia, Orenburg, Pionerskaya str. 11, of. 107. Tel.: +73532770512. E-mail: sgibnew72@yandex.ru. ORCID ID: 0000-0003-1866-1678
Kremleva Elena, MD, leading researcher, Laboratory for the study of the mechanisms of formation microbiocenoses of humans, Institute of Cellular and Intracellular Symbiosis, Ural Branch, Russian Academy of Sciences; Associate Professor, Department of Obstetrics and Gynecology, Orenburg State Medical University,
Ministry of Health of Russia. 460000, Russia, Orenburg, Pionerskaya str. 11, of. 107. Tel.: +73532770512. E-mail: kremlena1@mail.ru
Shchetinina Yuliya, PhD, Associate Professor, Department of Obstetrics and Gynecology, Orenburg State Medical University, Ministry of Health of Russia.
460000, Russia, Orenburg, Sovetskaya str. 6. Tel.: +73532310201. E-mail: koto-yuliya@yandex.ru
Cherkasova Yuliya, postgraduate, I, Institute of Cellular and Intracellular Symbiosis, Ural Branch, Russian Academy of Sciences.
460000, Russia, Orenburg, Pionerskaya str. 11, of. 107. Tel.: +73532770512. E-mail: yulya.cherkasova.2018@mail.ru
For citations: Sgibnev A.V., Kremleva E.A., Shchetinina Yu.S., Cherkasova Yu.I. Combined use of antibiotics and probiotics as a way to enhance the efficiency of treatment for genital infections. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (4): 113-8. (in Russian)
https://dx.doi.org/10.18565/aig.2018.4.113-118
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