The status of biocenosis in pregnant women with a history of recurrent miscarriage
Objective. To study the vaginal microbiocenosis in pregnant women with a habitual miscarriage in history with the use of various diagnostic methods.Solovyeva A.V., Gerasimova O.P., Ermolenko K.S., Gevorgyan D.A.
Material and methods. A retrospective study included an analysis of outpatient records of 36 patients aged 28–46 years old, the average age was 36.9 ± 0.4 years, who applied for miscarriage in 2015–2017.
Results. 30 women (83.3%) did not complain during pregnancy, but noticed that the amount of discharge from the genital tract increased slightly. In the first trimester, bacterial vaginosis was detected in 7 (19.4%), in the second - in 12 (33.3%), in the third - in 13 (36.1%) women. In the third trimester, aerobic vaginitis (IUSTI criteria, 2018) was also detected in 2 pregnant women in combination with bacterial vaginosis and Candida albicans of the genus. In patients with an established diagnosis of bacterial vaginosis, aerobic vaginitis in combination with candidiasis clindacin B prolong was prescribed.
Conclusion. In women with habitual miscarriage, pregnancy is often complicated by a violation of the vaginal biocenosis with the active growth of Candida spp. or without it. A comparative description of the results of smears on microflora, gonococci, trichomonads, and real-time PCR showed that it is a mistake to judge the state of the biocenosis only by the results of the description of smears.
Keywords
pregnancy
biocenosis
clindamycin
butoconazole
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Received 07.09.2018
Accepted 21.09.2018
About the Authors
Solovyova, Alina V., Doctor of medicine, professor of the Department of obstetrics and gynecology with the course of perinatology,Peoples Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 8. Tel.: +79854477928. E-mail: av_soloveva@mail.ru
Gerasimova, Olga P., Candidate of Medical Sciences, Head of Medical Center “Arbatlinik”.
121099, Russia, Moscow, 1st Smolensky pereulok, 21. Tel.: +79032816512. E-mail: detti-mag@mail.ru
Ermolenko, Kristina S., Candidate of Medical Sciences, assistant of the Department of obstetrics and gynecology with the course of perinatology,
Peoples Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 8. Tel.: +79197664984. E-mail: z.kristinast@yandex.ru
Gevorgyan, Dianna A., resident of the Department of obstetrics and gynecology with the course of perinatology, Peoples Friendship University of Russia.
117198, Russia, Moscow, Miklukho-Maklaya str. 8. Tel.: +79260687668. E-mail: diannagev@icloud.com
For citations: Solovyeva A.V., Gerasimova O.P., Ermolenko K.S., Gevorgyan D.A. The status of biocenosis in pregnant women with a history of recurrent miscarriage. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (10): 106-11. (in Russian)
https://dx.doi.org/10.18565/aig.2018.10.106-111
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