Systematic analysis of molecular synergy between folic acid and ferrous fumarate in iron deficiency anemia

Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Pavlovich S.V.

1) Institute of Pharmacoinformatics, Federal Research Center “Computer Science and Control”, Russian Academy of Sciences, Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
This paper presents the results of a systems-biology analysis of synergy between iron and folates, the two micronutrients most commonly used for the nutritional support of pregnancy. Both folates and iron are essential for the biosynthesis and biological effects of glutathione. Analysis of the symptomatology and molecular pathophysiology of iron deficiency anemia (IDA) has shown that folates are an apparent iron synergist in erythropoiesis. Folate and iron deficiencies are characteristic of thyroid dysfunction and hyperglycemia. As shown by the example of ferrous fumarate when choosing medications for the treatment of IDA and for the prevention of iron deficiency in a pregnant woman, it is necessary to take into account the important pharmaceutical characteristics of the iron substances used.
Conclusion: The advantages of the pharmaceutical substance of ferrous fumarate include high safety, high bioavailability of iron and proven efficacy in the treatment of IDA. The combination of ferrous fumarate and folic acid cannot only compensate for iron deficiency, but can also support the processes of erythropoiesis, eliminate hyperhomocysteinemia, and prevent folate-dependent fetal malformations.


ferrous fumarate
folic acid
nutritional support for pregnancy
treatment of iron deficiency anemia


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Received 12.12.2022

Accepted 19.12.2022

About the Authors

Olga A. Gromova, Dr. Med. Sci., Professor, Science Нead of the Institute of Pharmacoinformatics, Leading Researcher at the Department of Intellectual Systems, Federal Research Center “Computer Science and Control” of Russian Academy of Sciences,,,
119333, Russia, Moscow, Vavilova str., 42.
Ivan Yu. Torshin, PhD in Applied Mathematics, Institute of Pharmacoinformatics, Senior Researcher at the Department of Intellectual Systems, Federal Research Center “Computer Science and Control” of Russian Academy of Sciences,, 119333, Russia, Moscow, Vavilova str., 42.
Nana K. Tetruashvili, Dr. Med. Sci., Head of the 2nd Obstetrics Department of Pathology of Pregnancy, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia,, 117997, Russia, Moscow, Ac. Oparina str., 4.
Stanislav V. Pavlovich, PhD, Academic Secretary, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology, I.M. Sechenov First MSMU, Ministry of Health of Russia (Sechenov University),,,
117997, Russia, Moscow, Ac. Oparina str., 4.
Corresponding author: Olga A. Gromova,

Authors’ contributions: Gromova O.A. – investigation idea, writing the text; Torshin I.Yu. – material collection and processing, writing the text; Tetruashvili N.K. – editing the text; Pavlovich S.V. – investigation idea, writing the text. All the authors have contributed to the publication equally.
Conflicts of interest: All the authors declare that there is no need to disclose conflicts of interest in this publication.
Funding: The investigation has not been sponsored.
Acknowledgement: The calculations have been made according to State Assignment No. 0063-2019-0003 “Mathematical methods for data analysis and forecasting” using the infrastructure of the Center for Collective Use "High-Performance Computing and Big Data", Federal Research Center "Informatics and Control" of the Russian Academy of Sciences.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Pavlovich S.V. Systematic analysis of molecular synergy between folic acid and ferrous fumarate in iron deficiency anemia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 12: 178-186 (in Russian)

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