On prospects for using combinations of folic acid and active folates for the nutritional support of pregnancy

Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Galustyan A.N., Kuritsyna N.A.

1) Institute of Pharmacoinformatics, Federal Research Center of Informatics and Management, Russian Academy of Sciences, Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 3) Saint Petersburg State Pedagogical Medical University, Ministry of Health of Russia
Folic acid is most often used for the primary prevention of fetal malformations (FMFs). The prevention of FMFs and pregnancy pathologies with folates in a synergistic combination with other vitamins is very effective due to the widespread distribution of polyhypovitaminoses. Folic acid bioavailability substantially depends on the dose used and the genetic profile of a patient, so the promising trend is to use active folate forms (for example, 5-methyltetrahydrofolate (5-MTHF)). In this case, 5-MTHP can be used in combination with folic acid, since this provides an obvious pharmacokinetic advantage of maintaining more stable blood folate levels. If the dosage of folic acid in such combinations does not exceed 400 μg/day, folic acid will not lead to impaired metabolism of endogenous folates, including 5-MTHF.

Keywords

folic acid
5-methyltetrahydrofolate
pregnancy
Pregnoton Mama

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Received 27.03.2019

Accepted 19.04.2019

About the Authors

Gromova, Olga A., MD, professor, science head of the Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems,
Institute of Pharmacoinformatics, Federal Research Center of Informatics and Management, Russian Academy of Sciences.
119333, Russia, Moscow, Vavilova str. 42. Tel.: +74997833327. E-mail: unesco.gromova@gmail.com РИНЦ SPIN-код: 6317-9833,
AuthorID: 94901, Scopus Author ID: 7003589812, ORCID iD https://orcid.org/0000-0002-7663-710X, WOS ID J-4946-2017
Torshin, Ivan Yu., PhD in Applied Mathematics, senior researcher, Institute of Pharmacoinformatics, Federal Research Center of Informatics and Management,
Russian Academy of Sciences. 119333, Russia, Moscow, Vavilova str. 42. Tel.: +74997833327. E-mail: tiy135@ccas.ru
Scopus Author ID: 7003300274, РИНЦ SPIN-код: 1375-1114, AuthorID: 54104, ORCID iD: 0000-0002-2659-7998, WOS ID: C-7683-2018
Tetruashvili, Nana K., MD, head of the Department of Pregnancy Loss Prevention and Therapy, Academician V.I. Kulakov National Medical Research Center
of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: tetrauly@mail.ru
Galustiyan, Anna N., PhD, associate professor, head of the Department of Pharmacology with a course of clinical pharmacology and pharmacoeconomics,
Saint Petersburg State Pedagogical Medical University, Ministry of Health of Russia. 194100, Russia, St. Petersburg, Litovskaya str. 2. E-mail: klinika.spb@gmail.com
Kuritcyna, Natalia A., PhD, associate professor, Department of Pharmacology with a course of clinical pharmacology and pharmacoeconomics,
Saint Petersburg State Pedagogical Medical University, Ministry of Health of Russia. 194100, Russia, St. Petersburg, Litovskaya str. 2. E-mail: klinika.spb@gmail.com
ORCID: 0000-0002-0200-5097, SPIN-код: 4361-7365

For citation: Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Galustyan A.N., Kuritsyna N.A. On prospects for using combinations of folic acid and active folates for the nutritional support of pregnancy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (4): 87-94. (in Russian)
https://dx.doi.org/10.18565/aig.2019.4.87-94

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