The role of lipidomic studies in human reproduction and in the outcomes of infertility treatment programs using assisted reproductive technologies

DOI

https://dx.doi.org/10.18565/aig.2022.10.14-20

Fortygina Yu.A., Makarova N.P., Nepsha O.S., Lobanova N.N., Kalinina E.A.
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

Lipids and lipophilic trace elements are of increasing interest as potential non-invasive predictive molecules for in vitro fertilization outcomes. Their antioxidant and/or pro-inflammatory activities have an impact on female and male reproductive functions. Since the causes of fertility disorders may be related to metabolic imbalance, metabolomics can be applied to reproductive medicine to identify and quantify low-molecular-weight metabolites in follicular fluid and in the germ cells of couples undergoing assisted reproductive technologies. Studying the effect of lipids on the outcomes of assisted reproductive technologies in order to correct lipid metabolism disorders will help to improve live birth rates. Data from the Russian and foreign articles found in PubMed (http://pubmed.ncbi.nim.nih.gov) and published over the past 5 years were systematically analyzed. The paper presents data from studies investigating the lipidome of follicular fluid, spermatozoa and seminal plasma, blood plasma from couples and the possible prospects for studies in assisted reproductive technology programs.
Conclusion: Despite the extent of current investigations, the question of the combined mutual influence of the lipid profile of female and male gametes and blood of patients on the parameters of oogenesis, spermatogenesis, and embryogenesis, and, accordingly, on the outcomes of assisted reproductive technology programs, remains open. Further investigations are needed to study lipidome in order to predict the outcomes of treatment with assisted reproductive technologies and to develop possible interventions to correct the lipidome composition.

lipidomic analysis

follicular fluid

seminal plasma

spermatozoa

assisted reproductive technologies

infertility

Full text (in Russian)

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Received 10.06.2022

Accepted 31.08.2022

Iuliia A. Fortygina, postgraduate student, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of the Russian Federation, yu_fortygina@oparina4.ru, https://orcid.org/0000-0002-1251-0505, 117997, Russia, Moscow, Ac. Oparin str., 4.
Natalya P. Makarova, Dr. Bio. Sci., Leading Researcher, Department of IVF named after Prof. B.V. Leonov, Academician V.I. Kulakov National Medical Research Center
for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, np_makarova@oparina4.ru, https://orcid.org/0000-0003-8922-2878,
117997, Russia, Moscow, Ac. Oparin str., 4.
Oksana S. Nepsha, PhD (Bio), Researcher, Department of IVF named after Prof. B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, o_nepsha@oparina4.ru, https://orcid.org/0000-0002-9988-2810,
117997, Russia, Moscow, Ac. Oparin str., 4.
Nataliya N. Lobanova, Researcher, Department of IVF named after Prof. B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, n_lobanova@oparina4.ru, https://orcid.org/0000-0002-0818-4073, 117997, Russia, Moscow, Ac. Oparin str., 4.
Elena A. Kalinina, Dr. Med. Sci., Professor, Head of the IVF department named after Prof. B.V. Leonov, Academician V.I. Kulakov National Medical Research Center
for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, e_kalinina@oparina4.ru, https://orcid.org/0000-0002-8922-2878,
117997, Russia, Moscow, Ac. Oparin str., 4.
Corresponding author: Iuliia A. Fortygina, yu_fortygina@oparina4.ru

Authors' contributions: Fortygina Yu.A., Makarova N.P., Nepsha O.S., Lobanova N.N., Kalinina E.A. – development of the design of the investigation, obtaining data for analysis, reviewing publications on the topic of the article, analysis of the findings, writing the text of the manuscript.
Conflicts of interest: The authors declare that there are no possible conflicts of interests.
Funding: The investigation has not been sponsored.
For citation: Fortygina Yu.A., Makarova N.P., Nepsha O.S., Lobanova N.N., Kalinina E.A. The role of lipidomic studies in human reproduction and in the outcomes
of infertility treatment programs using assisted reproductive technologies.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 10: 14-20 (in Russian)
https://dx.doi.org/10.18565/aig.2022.10.14-20

The role of lipidomic studies in human reproduction and in the outcomes of infertility treatment programs using assisted reproductive technologies

Fortygina Yu.A., Makarova N.P., Nepsha O.S., Lobanova N.N., Kalinina E.A.

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