The role of phytoestrogens in the complex therapy and prevention of the recurrent lower urinary tract infection in climacteric patients

Nashivochnikova N.A., Krupin V.N., Zubova S.Yu., Leanovich V.E.

1) Privolzhsky Research Medical University, Ministry of Health of Russia, Nizhny Novgorod, Russia; 2) N.A. Semashko Nizhny Novgorod Regional Clinical Hospital, Nizhny Novgorod, Russia; 3) Akvion LLC, Moscow, Russia
Objective: To study the effect of Mense dietary supplements on the state of the urogenital zone in patients with recurrent lower urinary tract infection during peri- and postmenopause and to evaluate the risk of recurrent urinary tract infection.
Materials and methods: The study included 86 patients in peri– and postmenopause with the symptoms of vaginal and cystourethral atrophy and recurrent cystitis. The main group consisted of 44 patients, the control group included 42 patients. The patients of both groups received standard therapy for acute urinary infection. To prevent recurrent cystitis, all patients were administered medications containing cranberry proanthocyanidins. The patients were also recommended to consume not less than 1.5L of fluid per day and to maintain the proper hygiene of the urinary tract. The patients of the main group additionally received Mense dietary supplements, 1 or 2 capsules per day during a meal for one month. The state of pelvic venous hemodynamics and microcirculation of the bladder wall were assessed with the help of Doppler sonography and laser Doppler flowmetry. Bladder microcirculation parameters were measured using laser analyser of blood microcirculation (LAKK-02, Russia).
Results: During the study all the patients of the main group noticed the considerable improvement in general well-being, decrease in tenderness, relief of pain in the lower abdomen and discomfort in the urethra area after 1 and 6 months. The use of Mense dietary supplements in women with chronic recurrent cystitis in the period of peri– and postmenopause helps to achieve higher clinical effect due to the remarkable improvement in the circulation of the bladder wall and urethra and positive dynamics in pelvic venous blood flow.
Conclusion: The complex therapy containing Mense supplements with phytoestrogens for the recurrent infection of the urinary tract during peri– and postmenopause contributes to the improvement in the state of the urogenital zone, and also considerably reduces the number of cystitis recurrences.

Authors' contributions: Nashivochnikova N.A. – development of the study design, obtaining data for analysis, review of publications on the topic of the article, analysis of the data obtained, writing the text of the manuscript; Leanovich V.E. – review of publications on the topic of the article, writing the text of the manuscript; Krupin V.N. – data collection, analysis of the data obtained; Zubova S.Yu. – data acquisition for analysis.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The article was financially supported by the Akvion Company, Russia.
Ethical Approval: The study was approved by the Ethical Review Board of the Privolzhsky Research Medical University, Ministry of Health of Russia.
Patient Consent for Publication: All patients signed an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Nashivochnikova N.A., Krupin V.N., Zubova S.Yu., Leanovich V.E. The role of phytoestrogens
in the complex therapy and prevention of the recurrent lower urinary tract infection in climacteric patients.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (8): 141-152 (in Russian)


complex therapy
recurrent cystitis


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Received 29.06.2023

Accepted 18.08.2023

About the Authors

Natalya A. Nashivochnikova, PhD, Associate Professor at the Department of Urology named after E.V. Shakhov, Privolzhsky Research Medical University, Ministry of Health
of Russia, +79616354956,,, 603950, Russia, Nizhny Novgorod, Minin and Pozharsky sqr., 10/1.
Valentin N. Krupin, Dr. Med. Sci., Professor, Head of the Department of Urology named after. E.V. Shakhov, Privolzhsky Research Medical University,
Ministry of Health of Russia,, 603950, Russia, Nizhny Novgorod, pl. Minin and Pozharsky sqr., 10/1.
Svetlana Yu. Zubova, doctor of ultrasound diagnostics, N.A. Semashko Nizhny Novgorod Regional Clinical Hospital,, 603950, Russia, Nizhny Novgorod, Rodionova str., 190.
Victoria E. Leanovich, Medical director, Akvion LLC,,Х, 123112, Russia, Moscow, Presnenskaya nab., 8, build.1.
Corresponding author: Natalya A. Nashivochnikova,

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