Reproductive function realization in HIV-infected men
Objective. To analyze the peculiarities of reproductive function realization in HIV-infected men, the impactSelimova F.N., Perminova S.G., Mityurina E.V., Kozyrina N.V., Amyan T.S.
of human immunodeficiency virus (HIV) infection and antiretroviral therapy (ARVT) on the quality of gametes and the outcomes of assisted reproductive technology (ART) programs.
Material and methods. The review includes more than 50 foreign and Russian publications.
Results. The impact of HIV infection and ARVT on fertility, the quality of spermatozoa, and the effectiveness
of ART programs is discussed in HIV-infected men.
Conclusion. It becomes necessary to use of ART in serodiscordant couples with a HIV-positive man mainly to reduce the risks of vertical and horizontal transmission. To date, there is no clear evidence of the impact of HIV infection and ARVT on fertility, the quality of spermatozoa and their mitochondrial potential, and there remains debate about the outcomes of ART programs in married couples and a HIV-positive man.
Keywords
human immunodeficiency virus (HIV)
fertility
infertility
assisted reproductive technologies (ART)
in vitro fertilization (IVF)
antiretroviral therapy (ARVT)
References
1. Форма мониторинга Роспотребнадзора «Сведения о мероприятиях по профилактике ВИЧ-инфекции, гепатитов В и С, выявлению и лечению больных ВИЧ». 2017. Available at: https://spid-vich-zppp.ru/statistika/ofitsialnaya-statistika-vich-spid-rf-2016.html [Form of monitoring of Rospotrebnadzor “Information on measures for the prevention of HIV infection, hepatitis B and C, detection and treatment of HIV patients.” 2017. Available at: https://spid-vich-zppp.ru/statistika/ofitsialnaya-statistika-vich-spid-rf-2016.html (in Russian)]
2. AIDS Global Report. 2010. Available at: http://www.unaids.org/globalreport/Global_report.htm
3. Адамян Л.В., Афонина Л.Ю., Баранов И.И., Воронин Е.Е., Кан Н.Е., Кузьмин В.Н., Козырина Н.В., Покровский В.В., Садовникова В.Н., Юрин О.Г., Фомин Ю.А. Применение антиретровирусных препаратов в комплексе мер, направленных на профилактику передачи ВИЧ от матери ребенку. Клинические рекомендации (протокол лечения). М.; 2015. [Adamyan L.V., Afonina L.Yu., Baranov I.I., Voronin E.E., Kan N.E., Kuzmin V.N., Kozyrina N.V., Pokrovsky V.V., Sadovnikova V.N., Yurin O.G., Fomin Yu.A. The use of antiretroviral drugs in a package of measures aimed at preventing the transmission of HIV from mother to child. Clinical recommendations (protocol of treatment). Moscow; 2015. (in Russian)]
4. Краснопольская К.В., Назаренко Т.А., Гафуров Ю.Т. Место вспомогательных репродуктивных технологий в реализации репродуктивной функции у ВИЧ-инфицированных лиц. Российский вестник акушера-гинеколога. 2013; 13(3): 47-55. [Krasnopolskaya K.V., Nazarenko T.A., Gafurov Yu.T. Place of assisted reproductive technologies in the realization of reproductive function in HIV-infected individuals. The Russian bulletin of the obstetrician-gynecologist. 2013; 13(3): 47-55. (in Russian)]
5. Van Voorhis B.J., Martinez A., Mayer K., Anderson D.J. Detection of human immunodeficiency virus type 1 in semen from seropositive men using culture and polymerase chain reaction deoxyribonucleic acid amplification techniques. Fertil. Steril. 1991; 55(3): 588-99.
6. Castilla J., Del Romero J., Hernando V., Marincovich B., García S., Rodríguez C. Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV. J. Acquir. Immune Defic. Syndr. 2005; 40(1): 96-101.
7. Del Romero J., Castilla J., Hernando V., Rodríguez C., García S. Combined antiretroviral treatment and heterosexual transmission of HIV-1: cross sectional and prospective cohort study. BMJ. 2010; 340: c2205.
8. Cohen M.S., Chen Y.Q., McCauley M., Gamble T., Hosseinipour M.C., Kumarasamy N. et al. Prevention of HIV-1 infection with early antiretroviral therapy. N. Engl. J. Med. 2011; 365(6): 493-505.
9. Reynolds S.J., Makumbi F., Nakigozi G., Kagaayi J., Gray R.H., Wawer M. et al. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS. 2011; 25(4): 473-7.
10. Vernazza P., Hirschel B., Bernasconi E., Flepp M. HIV transmission under highly active antiretroviral therapy. Lancet. 2008; 372(9652): 1806-7.
11. Barreiro P., Castilla J.A., Labarga P., Soriano V. Is natural conception a valid option for HIV-serodiscordant couples? Hum. Reprod. 2007; 22(9): 2353-8.
12. Wilson D.P., Law M.G., Grulich A.E., Cooper D.A., Kaldor J.M. Relation between HIV viral load and infectiousness: a model-based analysis. Lancet. 2008; 372(9635): 314-20.
13. Vernazza P.L., Graf I., Sonnenberg-Schwan U., Geit M., Meurer A. Pre-exposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a child. AIDS. 2011; 25(16): 2005-8.
14. Stewart G.J., Tyler J.P., Cunningham A.L., Barr J.A., Driscoll G.L., Gold J., Lamont B.J. Transmission of human T-cell lymphotropic virus type III (HTLV-III) by artificial insemination by donor. Lancet. 1985; 2(8455): 581-5.
15. Nuovo G.J., Becker J., Simsir A., Margiotta M., Khalife G., Shevchuk M. HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization. Am. J. Pathol. 1994; 144(6): 1142-8.
16. Muciaccia B., Padula F., Gandini L., Lenzi A., Stefanini M. HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa. AIDS. 2005; 19(13): 1424-6.
17. Persico T., Savasi V., Ferrazzi E., Oneta M., Semprini A.E., Simoni G. Detection of human immunodeficiency virus-1 RNA and DNA by extractive and in situ PCR in unprocessed semen and seminal fractions isolated by semen-washing procedure. Hum. Reprod. 2006; 21(6): 1525-30.
18. Bujan L., Pasquier C., Labeyrie E., Lanusse-Crousse P., Morucci M., Daudin M. Insemination with isolated and virologically tested spermatozoa is a safe way for HIV-1 virus sero-discordant couples with an infected male partner to have a child. Fertil. Steril. 2004; 82(4): 857-62.
19. Coombs R.W., Reichelderfer P.S., Landay A.L. Recent observations on HIV type-1 infection in the genital tract of men and women. AIDS. 2003; 17(4): 455-80.
20. Ping L.H., Cohen M.S., Hoffman I., Vernazza P., Seillier-Moiseiwitsch F., Chakraborty H. et al. Effects of genital tract inflammation on human immunodeficiency virus type 1 V3 populations in blood and semen. J. Virol. 2000; 74(19): 8946-52.
21. Englert Y., Lesage B., Van Vooren J.P., Liesnard C., Place I., Vannin A.S. et al. Medically assisted reproduction in the presence of chronic viral diseases. Hum. Reprod. Update. 2004; 10(2): 149-62.
22. Kehl S., Weigel M., Müller D., Gentili M., Hornemann A., Sütterlin M. HIV-infection and modern antiretroviral therapy impair sperm quality. Arch. Gynecol. Obstet. 2011; 284(1): 229-33.
23. Bujan L., Sergerie M., Moinard N., Martinet S., Porte L., Massip P. et al. Decreased semen volume and spermatozoa motility in HIV-1-infected patients under antiretroviral treatment. J. Androl. 2007; 28(3): 444-52.
24. Pilatz A., Discher T., Lochnit G., Wolf J., Schuppe H.C., Schüttler C.G. et al. Semen quality in HIV patients under stable antiretroviral therapy is impaired compared to WHO 2010 reference values and on sperm proteome level. AIDS. 2014; 28(6): 875-80.
25. van Leeuwen E., Cornelissen M., de Vries J.W., Lowe S.H., Jurriaans S., Repping S., van der Veen F. Semen parameters of a semen donor before and after infection with human immunodeficiency virus type 1: case report. Hum. Reprod. 2004; 19(12): 2845-8.
26. van Leeuwen E., Wit F.W., Prins J.M., Reiss P., van der Veen F., Repping S. Semen quality remains stable during 96 weeks of untreated human immunodeficiency virus-1 infection. Fertil. Steril. 2008; 90(3): 636-41.
27. Nicopoullos J.D., Almeida P., Vourliotis M., Gilling-Smith C. A decade of the sperm-washing programme: correlation between markers of HIV and seminal parameters. HIV Med. 2011; 12(4): 195-201.
28. Robbins W.A., Witt K.L., Haseman J.K., Dunson D.B., Troiani L., Cohen M.S. et al. Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection. J. Infect. Dis. 2001;184(2): 127-35.
29. Savasi V., Mandia L., Laoreti A., Cetin I. Reproductive assistance in HIV serodiscordant couples. Hum. Reprod. Update. 2013; 19(2): 136-50.
30. Oneta M., Savasi V., Parrilla B. et al. Does antiretroviral therapy affect DNA integrity in spermatozoa of HIV-1 infected patients? In: 27th Annual Meeting of ESHRE. Stockholm, Sweden, 3 July-6 July, 2011.
31. Zhu Z., Hitchcock M.J., Sommadossi J.P. Metabolism and DNA interaction of 2’,3’-didehydro-2’,3’-dideoxythymidine in human bone marrow cells. Mol. Pharmacol. 1991; 40(5): 838-45.
32. Maisonneuve C., Igoudjil A., Begriche K., Lettéron P., Guimont M.C., Bastin J. et al. Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting. Antivir. Ther. 2004; 9(5): 801-10.
33. Pavili L., Daudin M., Moinard N., Walschaerts M., Cuzin L., Massip P. et al. Decrease of mitochondrial DNA level in sperm from patients infected with human immunodeficiency virus-1 linked to nucleoside analogue reverse transcriptase inhibitor. Fertil. Steril. 2010; 94(6): 2151-6.
34. Van Leewen L., Repping S., de Baar M.P., Wit F.W., Prins J.M., van der Veen F., Reiss P. Increase of spermatozoal mtDNA copy numbers during first twelve weeks of first-line HAART. In: van Leeuwen E. Male reproduction and HIV-1 infection. 2009: 75-86.
35. Semprini A.E., Levi-Setti P., Bozzo M., Ravizza M., Taglioretti A., Sulpizio P. et al. Insemination of HIV-negative women with processed semen of HIV-positive partners. Lancet. 1992; 340(8831): 1317-9.
36. Zamora M.J., Obradors A., Woodward B., Vernaeve V., Vassena R. 37. Semen residual viral load and reproductive outcomes in HIV-infected men undergoing ICSI after extended semen preparation. Reprod. Biomed. 2016; 32(6): 584-90.
37. Politch J.A., Xu C., Tucker L., Anderson D.J. Separation of human immunodeficiency virus type 1 from motile sperm by the double tube gradient method versus other methods. Fertil. Steril. 2004; 81(2): 440-7.
38. Hanabusa H., Kuji N., Kato S., Tagami H., Kaneko S., Tanaka H., Yoshimura Y. An evaluation of semen processing methods for eliminating HIV-1. AIDS. 2000; 14(11): 1611–6.
39. Loskutoff N.M., Huyser C., Singh R., Walker D.L., Thornhill A.R., Morris L., Webber L. Use of a novel washing method combining multiple density gradients and trypsin for removing human immunodeficiency virus-1 and hepatitis C virus from semen. Fertil. Steril. 2005; 84(4): 1001-10.
40. Kato S., Hanabusa H., Kaneko S., Takakuwa K., Suzuki M., Kuji N. et al. Complete removal of HIV-1 RNA and proviral DNA from semen by the swim-up method: assisted reproduction technique using spermatozoa free from HIV-1. AIDS. 2006; 20(7): 967-73.
41. Sauer M.V., Chang P.L. Establishing a clinical program for human immunodeficiency virus 1-seropositive men to father seronegative children by means of in vitro fertilization with intracytoplasmic sperm injection. Am. J. Obstet. Gynecol. 2002; 186(4): 627-33.
42. Garrido N., Meseguer M., Remohí J., Simón C., Pellicer A. Semen characteristics in human immunodeficiency virus (HIV)- and hepatitis C (HCV)-seropositive males: predictors of the success of viral removal after sperm washing. Hum. Reprod. 2005; 20(4): 1028-34.
43. Mencaglia L., Falcone P., Lentini G.M., Consigli S., Pisoni M., Lofiego V. et al. ICSI for treatment of human immunodeficiency virus and hepatitis C virus-serodiscordant couples with infected male partner. Hum. Reprod. 2005; 20(8): 2242-6.
44. Savasi V., Ferrazzi E., Lanzani C., Oneta M., Parrilla B., Persico T. Safety of sperm washing and ART outcome in 741 HIV-1-serodiscordant couples. Hum. Reprod. 2007; 22(3): 772-7.
45. Oliva G., Pons J.M.V. Lavado de semen en parejas VIH serodiscordantes para su uso en técnicas de reproducción humana asistida. Barcelona: Agència d’Avaluació de Tecnologia i Recerca Mèdiques; 2004
46. Barreiro P., del Romero J., Leal M., Hernando V., Asencio R., de Mendoza C. et al. Natural pregnancies in HIV-serodiscordant couples receiving successful antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 2006; 43(3): 324-6.
47. Кузьмин В.Н., Машина М.А. ВИЧ-инфекция и экстракорпоральное оплодотворение: проблема и пути решения. Лечащий врач. 2015; 1: 87-91. [Kuzmin V.N., Mashina M.A. HIV infection and in vitro fertilization: the problem and solutions. Lechaschiy vrach. 2015; 1: 87-91. (in Russian)]
48. Prisant N., Tubiana R., Lefebvre G., Lebray P., Marcelin A.G., Thibault V. et al. HIV-1 or hepatitis C chronic infection in serodiscordant infertile couples has no impact on infertility treatment outcome. Fertil. Steril. 2010; 93(3): 1020-3.
49. Sauer M.V., Wang J.G., Douglas N.C., Nakhuda G.S., Vardhana P., Jovanovic V., Guarnaccia M.M. Providing fertility care to men seropositive for human immunodeficiency virus: reviewing 10 years of experience and 420 consecutive cycles of in vitro fertilization and intracytoplasmic sperm injection. Fertil. Steril. 2009; 91(6): 2455-60.
50. Nicopoullos J.D., Almeida P., Vourliotis M., Gilling-Smith C. A decade of the United Kingdom sperm-washing program: untangling the transatlantic divide. Fertil. Steril. 2010; 94(6): 2458-61.
51. Приказ Министерства здравоохранения РФ № 107н от 30 августа 2012 г. „О порядке использования вспомогательных репродуктивных технологий, противопоказаниях и ограничениях к их применению”. [Order of the Ministry of Health of the Russian Federation No. 107n of August 30, 2012 “On the use of assisted reproductive technologies, contraindications and limitations to their use.” (in Russian)]
52. Riley L.E., Yawetz S. Case records of the Massachusetts General Hospital. Case 32-2005. A 34-year-old HIV-positive woman who desired to become pregnant. N. Engl. J. Med. 2005; 353(16): 1725-32.
53. Ruibal M., Larcher J.S. Riesgo de transmisión del HIV en parejas serodiscordantes en tratamiento de fertilidad. Reproduccion. 2009; 24: 115-27.
54. Steenvoorden M.M., Cornelissen M., van Leeuwen E., Schuurman N.M., Egberink H.F., Berkhout B. et al. Integration of immunodeficiency virus in oocytes via intracytoplasmic injection: possible but extremely unlikely. Fertil. Steril. 2012; 98(1): 173-7.
55. Grinsztejn B.G., de Andrade C.A., Hökerberg Y.H., de Souza C.T., Friedman R.K., Passos S.R. Systematic review of the effectiveness and safety of assisted reproduction techniques in couples serodiscordant for human immunodeficiency virus where the man is positive. Fertil. Steril. 2011; 95(5): 1684-90.
56. Никитин С.В., Мусатов В.Б. Вспомогательные методы репродукции и ВИЧ. Проблемы репродукции. 2009; Специальный выпуск: III Международный конгресс по репродуктивной медицине: 286. [Nikitin S.V., Musatov V.B. Supportive methods of reproduction and HIV. Reproduction problems. 2009; Special issue: III International Congress on Reproductive Medicine: 286. (in Russian)]
57. Eke A.C., Oragwu C. Sperm washing to prevent HIV transmission from HIV-infected men but allowing conception in sero-discordant couples. Cochrane Database Syst. Rev. 2011; (1): CD008498.
58. Márquez M., Romero-Cores P., Montes-Oca M., Martín-Aspas A., Soto-Cárdenas M.J., Guerrero F. et al. Immune activation response in chronic HIV-infected patients: influence of Hepatitis C virus coinfection. PLoS One. 2015; 10(3): e0119568.
59. Melo M.A., Meseguer M., Bellver J., Remohí J., Pellicer A., Garrido N. Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome. Fertil. Steril. 2008; 89(1): 141-50.
Received 08.11.2017
Accepted 22.12.2017
About the Authors
Selimova Fatima Nasredinovna, post-graduate student of the 1st gynecological department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79268887755. E-mail: doc.fselimova@mail.ruPerminova Svetlana Grigoryevna, MD, leading research assistant of the 1st gynecological department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79162021687. E-mail: perisvet@list.ru
Mityurina Elena Viktorovna, MD, doctor of the 1st gynecologic department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named
after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79647967465. E-mail: mity-elena@yandex.ru
Kozyrina Nadezhda Vladimirovna, Ph.D., scientific employee of the Central Research Institute of Epidemiology, Federal Service for Supervision
of Consumer Rights Protection and Human Well-Being. 111123, Russia, Moscow, Novogireevskaya str. 3a. Tel.: +79167151018. E-mail: nad-kozyrina@yandex.ru
Amyan Tatiana Sergeevna, post-graduate student of the 3rd gynecological department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79261632833. E-mail: amyantanya@rambler.ru
For citations: Selimova F.N., Perminova S.G., Mityurina E.V., Kozyrina N.V.,
Amyan T.S. Reproductive function realization in HIV-infected men.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (5): 36-42. (in Russian)
https://dx.doi.org/10.18565/aig.2018.5.36-42
Similar Articles
