Splenic rupture as an inaugural manifestation of multimorbidity: essential thrombocythemia and congenital thrombophilia
Background. Essential thrombocythemia is a malignant myeloproliferative disease that can cause obstetric complications, such as severe preeclampsia, fetal growth restriction, miscarriage, postpartum hemorrhage, and multiple venous thromboses. Untimely diagnosis can lead to rupture of parenchymal organs, for example, spontaneous splenic rupture.Padrul M.M., Zhelobov V.G., Sadykova G.K., Zaplatina V.S., Kobaidze E.G., Voronova A.A.
Case report. The paper describes a clinical case of a pregnant woman with pregestationally undiagnosed congenital thrombophilia, essential thrombocythemia, which manifested itself during pregnancy as spontaneous splenic rupture and multiple venous thromboses.
Conclusion. Timely diagnosis and adequate treatment in accordance with national clinical guidelines for the diagnosis and treatment of Ph-negative myeloproliferative diseases, including essential thrombocythemia (2016) and congenital thrombophilia, can ensure a favorable pregnancy outcome.
Keywords
myeloproliferative diseases
essential thrombocythemia
congenital thrombophilia
pregnancy
multiple thromboses
splenic rupture
References
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Received 19.03.2020
Accepted 01.10.2020
About the Authors
Mikhail M. Padrul, Dr. Med. Sci., professor, Head of the Department of Obstetrics and Gynecology №1, Academician E.A. Wagner Perm State Medical University,Ministry of Health of Russia. Tel.: +7(908)271-64-66. E-mail: m-padrul@mail.ru. 614990, Russia, Perm, Petropavlovskaya str., 26.
Vladimir G. Zhelobov, Dr. Med. Sci., professor, Head of the Department of Polyclinic Therapy, Academician E.A. Wagner Perm State Medical University,
Ministry of Health of Russia. Tel.: +7(908)279-66-54. E-mail: zhelobov.vg@psma.ru. 614990, Russia, Perm, Petropavlovskaya str., 26.
Gulnara K. Sadykova, PhD, associate professor of the Department of Obstetrics and Gynecology №1, Academician E.A. Wagner Perm State Medical University,
Ministry of Health of Russia. Tel.: +7(902)479-87-42. E-mail: gulnara-sadykova@mail.ru. 614990, Russia, Perm, Petropavlovskaya str., 26.
Vera S. Zaplatina, PhD, associate professor of the Department of Obstetrics and Gynecology №1, Academician E.A. Wagner Perm State Medical University,
Ministry of Health of Russia. Tel.: +7(912)788-89-63. E-mail: zaplatina-vera@mail.ru. 614990, Russia, Perm, Petropavlovskaya str., 26.
Ekaterina G. Kobaidze, Dr. Med. Sci., associate professor of the Department of Obstetrics and Gynecology №1, Academician E.A. Wagner Perm State Medical University, Ministry of Health of Russia. Tel.: +7(912)783-70-77. E-mail: eka7i@yahoo.com. 614990, Russia, Perm, Petropavlovskaya str., 26.
Anna A. Voronova, 6th year student of the medical faculty, Academician E.A. Wagner Perm State Medical University, Ministry of Health of Russia.
Tel.: +7(909)109-41-27. E-mail: voronova.anna96@yandex.ru. 614990, Russia, Perm, Petropavlovskaya str., 26.
For citation: Padrul M.M., Zhelobov V.G., Sadykova G.K., Zaplatina V.S., Kobaidze E.G., Voronova A.A. Splenic rupture as an inaugural manifestation of multimorbidity: essential thrombocythemia and congenital thrombophilia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 1: 206-211 (in Russian)
https://dx.doi.org/10.18565/aig.2021.1.206-211
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