Fetal macrosomia: prediction, prevention, and tactics for management of pregnancy and delivery

Odinokova V.A., Shmakov R.G., Chagovets V.V.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To analyze the data available in the literature on current methods for prediction, prevention, and management tactics of pregnancy and delivery in fetal macrosomia.
Material and methods. The review includes the data of Russian and foreign articles published in the past 10 years and found in Pubmed on this topic.
Results. The risk factors of fetal macrosomia and current methods for its predicting were analyzed in healthy pregnant women and patients with metabolic disorders. The focus was on the role of lipids as biomarkers for the development of macrosomia. The review considers the main methods for the diagnosis, prevention, and tactics for management of pregnancy and delivery in fetal macrosomia.
Conclusion. There is a need for further investigations of the pathogenetic features of the development of macrosomia in order to elaborate new approaches to its early prediction and prevention. The improved tactics for management for pregnancy and delivery in this complication will improve maternal and perinatal outcomes.

Keywords

pregnancy
childbirth
fetal macrosomia
biomarkers for macrosomia
lipids
adipokines
leptin
adiponectin

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Received 09.06.2017

Accepted 23.06.2017

About the Authors

Odinokova V.A., Postgraduate student of maternity departments, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79057240264. E-mail: v_odinokova@oparina4.ru
Shmakov R.G., MD, PhD, the chief medical officer, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387300. E-mail: r_shmakov@oparina4.ru
Chagovec V.V., PhD, Senior Researcher of Proteomics of Human Reproduction, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79265626590. E-mail: vvchagovets@gmail.com

For citations: Odinokova V.A., Shmakov R.G., Chagovets V.V. Fetal macrosomia:
prediction, prevention, and tactics for management of pregnancy and delivery.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (1): 14-20. (in Russian)
https://dx.doi.org/10.18565/aig.2018.1.14-20

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