Prediction of preeclampsia during extended first-trimester combined prenatal screening

Lemeshevskaya T.V., Pribushenya O.V.

Republican Scientific and Practical Center “Mother and Child”, Minsk, Belarus
Objective. To evaluate the possibility of using anamnestic data, biophysical indicators, and biochemical markers for combined prenatal screening to predict preeclampsia in the first trimester of pregnancy.
Subjects and methods. 511 patients (27 with preeclampsia) with singleton pregnancy at 10-13 weeks gestation were examined. Anamnestic data, systolic blood pressure (SBP), and uterine artery pulsatility index (PI), and trophoblastic proteins were explored. The diagnostic threshold (cut-off point) of the analyzed factors was determined by ROC analysis.
Results. The normal range was 0.94-1.10 MoM for SBP, 0.87-1.27 MoM for PI, the median placental growth factor was 1.02 (0.67-1.59) MoM. The authors developed a scoring table to predict preeclampsia, using 9 factors, for each a diagnostic cut-off being calculated in scores. A patient with a sum equal to (-2) points or more (the diagnostic cut-off) belongs to a group at high risk for preeclampsia.
Conclusion. The method developed to predict preeclampsia in the first trimester of pregnancy has a useful estimate (AUC = 0.82±0.052; LR+, 3.21; and LR-, 0.29) and can be used in clinical practice.


combined prenatal screening

Supplementary Materials

  1. Table 1. Comparative characteristics of age, anthropometric and anamnestic data in study groups
  2. Table 2. Evaluation results of MAP, fetal ultrasound and uterine artery Doppler in the study groups, Me (25%-75%)
  3. Table 3. Biochemical markers results in the study groups, МоМ, Ме (25%-75%)
  4. Table 4. ROC-analysis findings of anthropometric data, biophysical indicators and biochemical markers
  5. Table 5. Probability of risk factors presence in preeclampsia patients based on odds ratio
  6. Table 6. Table of preeclampsia prediction in the first trimester of pregnancy
  7. Table 7. ROC-analysis findings of the preeclampsia prediction method


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Received 16.08.2017

Accepted 22.09.2017

About the Authors

Tatyana V. Lemeshevskaya, MD, PhD-student of the Scientific Laboratory for Medical Genetics, Republican Scientific and Practical Center “Mother and Child”. 220053, Belarus, Minsk, Orlovskaya str. 66. Tel.: (37517) 233-25-86. E-mail: ORCID ID 0000-0003-3911-2715
Oksana V. Pribushenya, MD, PhD, chief of the Scientific Laboratory for Medical Genetics, Republican Scientific and Practical Center “Mother and Child”. 220053, Belarus, Minsk, Orlovskaya str. 66

For citations: Lemeshevskaya T.V., Pribushenya O.V. Prediction of preeclampsia during extended first-trimester combined prenatal screening. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (12): 52-9. (in Russian)

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