Prediction of outcomes in assisted reproductive technology programs by determining telomere length and telomerase activity in cumulus cells and lymphocytes

Kraevaya E.E., Nalobin D.S., Glukhov A.I., Makarova N.P., Kalinina E.A.

1 Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia; 2 M.V. Lomonosov Moscow State University, Moscow 119991, Leninskie gori, 1, Russia
Objective. To carry out a systematic analysis of scientific data on the efficiency of determining telomere length and telomerase activity in follicular cumulus cells and peripheral blood lymphocytes, as well as a correlation of this indicator with the outcomes of in vitro fertilization programs.
Material and methods. The review includes the data of foreign and Russian articles published in the past 7 years and found in Pubmed on this topic.
Results. Based on the analyzed literature data, the authors have concluded that the study of telomere length and telomerase activity in the follicular cumulus cells and peripheral blood lymphocytes is a relevant and promising method for predicting the outcomes of assisted reproductive technology programs.
Conclusion. There is a need for further investigations assessing the correlation of telomere length and telomerase activity in the follicular cumulus cells and peripheral blood lymphocytes with the quality of oocytes and embryos, as well as with the effectiveness of infertility treatment programs involving in vitro fertilization techniques.

Keywords

assisted reproductive technologies
telomeres
telomerase activity
cumulus cells
oocyte
lymphocyte
in vitro fertilization

References

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Received 16.01.2017

Accepted 17.02.2017

About the Authors

Kraevaya Elizaveta Evgenievna, junior researcher of department of assisted reproductive technology in treating sterility, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954382501. E-mail: e_kraevaya@ oparina4.ru
Nalobin Denis Sergeevich, PhD, senior researcher of the Biological Faculty, M.V. Lomonosov Moscow State University.
119991, Russia, Moscow, Leninskie gori, 1. Tel.: +74959394452. E-mail: Nalobin@mail.bio.msu.ru
Glukhov Alexandr Ivanovich, Sc.D., Professor, Leading Researcher of the Biological Faculty, M.V. Lomonosov Moscow State University.
119991, Russia, Moscow, Leninskie gori, 1. Tel.: +74959394452. E-mail: glukhov.ai@1msmu.ru
Makarova Natalia Petrovna, PhD, Senior Researcher of department of assisted reproductive technology in treating sterility, Research Center of Obstetrics,
Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954381341. E-mail: np_makarova@ oparina4.ru
Kalinina Elena Anatolievna, MD, Associate Professor, The chief of department of assisted reproductive technology in treating sterility, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954381341. E-mail: e_kalinina@oparina4.ru

For citations: Kraevaya E.E., Nalobin D.S., Glukhov A.I., Makarova N.P., Kalinina E.A. Prediction of outcomes in assisted reproductive technology programs by determining telomere length and telomerase activity in cumulus cells and lymphocytes. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (12): 26-30. (in Russian)
https://dx.doi.org/10.18565/aig.2017.12.26-30

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