Prediction and early diagnosis of preeclampsia: scientific perspectives and clinical opportunities

Khodzhaeva Z.S., Oshkhunova M.S., Muminova K.T., Gorina K.A., Kholin A.M.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Preeclampsia (PE) is a clinical syndrome specific to pregnancy and the postpartum period, which complicates 3–8% of all pregnancies, is the main cause of maternal and perinatal morbidity and mortality, and reduces quality of life in a woman even with a successful labor outcome. This review presents an update on the possibilities for early prediction of preeclampsia. It includes scientific publications by foreign and Russian authors for the last 10 years, which have been found in the Pubmed database and other available search platforms: Cochrane, Web of Science, MEDLINE, and Google Scholar. The review gives information on the current results of studying the pathogenesis of preeclampsia and searching for its molecular predictors, by using postgenomic technologies, genome-wide association studies (GWAS), and epigenetics.
Conclusion: Further investigations are needed to search for and validate the laboratory markers of PE both to predict and prevent the risk of developing severe forms of this condition.


diagnosis of preeclampsia
omics technologies


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Received 15.09.2022

Accepted 14.10.2022

About the Authors

Zulfiya S. Khodzhaeva, M.D., Professor, Deputy Director of Obstetrics Institute, Academician V.I. Kulakov National Medical Research Center for Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia, +7(916)407-75-67,,,
117997, Russia, Moscow, Akademika Oparina str., 4.
Madina S. Оshkhunova, graduate student of the High Risk Pregnancy Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(917)577-12-77,,, 117997, Russia, Moscow, Akademika Oparina str., 4.
Kamilla T. Muminova, PhD, Researcher of the High Risk Pregnancy Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(916)373-77-07,,, 117997, Russia, Moscow, Akademika Oparina str., 4.
Kseniia A. Gorina, PhD, Researcher of the High Risk Pregnancy Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(926)649-77-32,,,
117997, Russia, Moscow, Akademika Oparina str., 4.
Alexey M. Kholin, PhD, Head of the Telemedicine Section of the Department of Regional Cooperation and Integration, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(495)438-25-38,,,
117997, Russia, Moscow, Akademika Oparina str., 4.

Authors’ contributions: Khodzhaeva Z.S., Oshkhunova M.S., Muminova K.T., Gorina K.A. – search for publications on the problem, their translation, writing the text of the manuscript.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has been conducted within the framework of the State Assignment of the Ministry of Health of the Russian Federation “Rationale for personalized approaches to antihypertensive therapy in HD and PE” under No. 121040600435-0.
For citation: Khodzhaeva Z.S., Oshkhunova M.S., Muminova K.T., Gorina K.A., Kholin A.M. Prediction and early diagnosis of preeclampsia: scientific perspectives and clinical opportunities.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 12: 57-65 (in Russian)

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