Prevention of recurrent urinary tract infectious diseases and edemas in pregnant women, by using cranberry (Oxycoccus) preparations
Objective. To investigate the efficiency of using cranberry (Oxycoccus) extract capsules in pregnant women with urinary tract infections and to assess the frequency of disease exacerbations, perinatal outcomes, and the efficiency of the preparation for pregnancy-induced edemas.Solovyeva A.V., Kuznetsova O.A., Ermolenko K.S.
Subjects and methods. The investigation enrolled 195 pregnant women aged 20 to 44 years in the first and second trimesters after an infection exacerbation or asymptomatic bacteriuria identified by urinalysis. The women were proposed to take one capsule containing cranberry extract (phytolysin prenatal) thrice daily during antibiotic therapy and then one capsule once daily for 28-30 days.
Results. There was term labor in 188 (96.4%), premature birth in 2 (1%), and late miscarriage at 21–22 weeks’ gestation in 1 (0.5%) patient with type 1 diabetes mellitus and fetal congenital malformations. Eleven (5.6%)
of the 195 women taking cranberry extract capsules were found to have adverse reactions: heartburn
(n = 6 (3.1%)) gastric pain (n = 4 (2.1%)), nausea/vomiting (n = 1 (0.5%)), and diarrhea (n = 1 (0.5%)).
With the use of phytolysin prenatal, there was a reduction of edema in the lower extremities, hands, and face.
Conclusion. The clinical research covering 195 pregnant women with urinary tract diseases confirmed the efficacy of cranberry extract in preventing urinary tract infection exacerbations during pregnancy. Rare side effects confirmed the safety of the agent. Phytolysin prenatal may also be recommended for pregnant women with edemas.
Keywords
urinary tract infection
bacteriuria
pregnancy
cranberry extract
lower-extremity edemas
Supplementary Materials
References
1. Mazzulli T. Resistance trends in urinary tract pathogens and impact on management. J. Urol. 2002. 168(4, Pt 2): 1720-2.
2. Rüden H., Gastmeier P., Daschner F.D., Schumacher M. Nosocomial and community-acquired infections in Germany. Summary of the results of the First National Prevalence Study (NIDEP). Infection. 1997; 25(4): 199-202.
3. Tambyah P., Olyszyna D.P., Tenke P., Koves P. Urinary catheters and drainage systems: definition, epidemiology and risk factors. In: Naber K.G., Schaeffer A.J., Heyns C.F., Matsumoto T., Shoskes D.A., Bjerklund Johansen T.E., eds. Urogenital infections. Arnhem, The Netherlands: European Association of Urology; 2010: 523-31.
4. Bjerklund Johansen T.E., Cek M., Naber K., Stratchounski L., Svendsen M.V., Tenke P. Prevalence of hospital-acquired urinary tract infections in urology departments. Eur. Urol. 2007; 51(4): 1100-11.
5. Foxman B., Cronenwett A.E., Spino C., Berger M.B., Morgan D.M. Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial. Am. J. Obstet. Gynecol. 2015; 213(2): 194. e1-8.
6. Afshar K., Stothers L., Scott H., MacNeily A.E. Cranberry juice for the prevention of pediatric urinary tract infection: А randomized controlled trial. J. Urol. 2012; 188(4, Suppl.): 1584-7.
7. Di Martino P., Agniel R., David K., Templer C., Gaillard J.L., Denys P., Botto H. Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: a double-blind randomized placebo-controlled cross-over trial. World J. Urol. 2006; 24(1): 21-7.
8. Gupta K., Chou M.Y., Howell A., Wobbe C., Grady R., Stapleton A.E. Cranberry products inhibit adherence of pmbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J. Urol. 2007; 177(6): 2357-60.
9. Сапрыгин В.Г., Кушнерова Н.Ф. Природные олигомерные проантоцианидины – перспективные регуляторы метаболических нарушений. Вестник Дальневосточного отделения Российской академии наук. 2006; 2: 81-90. [Saprygin V.G., Kushnerova N.F. Natural oligomeric proanthocyanidins are promising regulators of metabolic disorders. Bulletin of the Far Eastern Branch of the Russian Academy of Sciences. 2006; 2: 81-90. (in Russian)]
10. Heitmann K., Nordeng H., Holst L. Pregnancy outcome after use of cranberry in pregnancy: Тhe Norwegian Mother and Child Cohort Study. BMC Complement Altern. Med. 2013; 13: 345.
Received 08.12.2017
Accepted 22.12.2017
About the Authors
Solovyeva Alina Viktorovna, MD, professor of the obstetrics department of gynecology and reproductive medicine, Peoples’ Friendship University of Russia,Ministry of Education and Science. 117198, Russia, Moscow, Miklukho-Maklaya str. 6. E-mail: av_soloveva@mail.ru
Kuznetsova Olga Alekseevna, MD, associate professor of the obstetrics and gynecology department with a course in perinatology, Peoples’ Friendship University of Russia, Ministry of Education and Science. 117198, Russia, Moscow, Miklukho-Maklaya str. 6. E-mail: koa.15@mail.ru
Ermolenko Kristina Stanislavovna, MD, Assistant of the Department of Obstetrics and Gynecology with the course of perinatology, Peoples’ Friendship University of Russia, Ministry of Education and Science. 117198, Russia, Moscow, Miklukho-Maklaya str. 6. E-mail: k.s.emolenko@yandex.ru
For citations: Solovyeva A.V., Kuznetsova O.A., Ermolenko K.S. Prevention of recurrent urinary tract infectious diseases and edemas in pregnant women, by using cranberry (Oxycoccus) preparations. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (2): 126-30. (in Russian)
https://dx.doi.org/10.18565/aig.2018.2.126-130
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