Premature birth: past restrictions and new opportunities

Gorina K.A., Khodzhaeva Z.S., Belousov D.M., Baranov I.I., Gokhberg Ya.A., Pashchenko A.A.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
The data available in the world literature on studies of infection and inflammation as a factor that leads to premature birth have been sought and analyzed. Premature birth is the central problem of modern obstetrics, the leading cause of perinatal and infant morbidity and mortality. New potential methods for the diagnosis of spontaneous premature birth and preterm amniorrhea, as well as the basic stages of the pathogenesis of this process have been analyzed in detail. Diagnostic transabdominal ultrasound-guided amniocentesis should be considered as an important element in the diagnostic verification of threatening and imminent preterm births with subsequent correction of their obstetric management according to the findings.

Keywords

premature birth
amniocentesis
intra-amniotic inflammation
intra-amniotic infection
perinatal outcomes

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Received 19.06.2019

Accepted 21.06.2019

About the Authors

Ksenia A. Gorina, Junior researcher the Department of Pregnancy Pathology, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Healthcare of Russian Federation. Phone: +7 (926)649-77-32. E-mail: k_gorina@oparina4.ru
117997, Russia, Moscow, Akademika Oparina str. 4.
Zulfiya S. Khodzhaeva, M.D., Professor, Head of High Risk Pregnancy Dept,
National Medical Research Center for Obstetrics, Gynecology and Perinatology
named after Academician V.I. Kulakov Ministry of Healthcare of Russian Federation, Phone: +7(916)407-75-67E-mail: zkhodjaeva@mail.ru
117997, Russia, Moscow, Akademika Oparina str. 4.
Dmitry M. Belousov, ultrasound department specialist National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician
V.I. Kulakov Ministry of Healthcare of Russian Federation. Phone: +7(925)506-51-46. E-mail: d_belousov@oparina4.ru
117997, Russia, Moscow, Akademika Oparina str. 4.
Igor I. Baranov, M.D., Professor, Head of science-education department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov Ministry of Healthcare of Russian Federation. Phone: +7 (495)438 94 92. E-mail: i_baranov@oparina4.ru
117997, Russia, Moscow, Akademika Oparina str. 4.
Yael A. Gokhberg, clinical resident, «National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov» Ministry
of Healthcare of Russia. Phone: + 7(964) 794-79-12. E-mail: dr.yaelgokhberg@gmail.com
117997, Russia, Moscow, Akademika Oparina str. 4.
Alexander A. Pashchenko, clinical resident, «National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov» Ministry
of Healthcare of Russia. Phone: +7(916)177-72-49. E-mail: al.pashenko2018@gmail.com. 117997, Russia, Moscow, Akademika Oparina str. 4

For citation: Gorina K.A., Khodzhaeva Z.S., Belousov D.M., Baranov I.I., Gokhberg Ya.A., Pashchenko A.A. Premature birth: past restrictions and new opportunities.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 1: 12-19. (In Russian).
https://dx.doi.org/10.18565/aig.2020.1.12-119

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