Pregravid preparation in patients with the thin endometrium in assisted reproductive technology programs
Objective. To evaluate the efficiency of pregravid preparation using a specialized complex and hormonal therapy in patients with diagnosed infertility and clinical presentations of the thin endometrium.Serebrennikova K.G., Kuznetsova E.P., Vanke E.S., Ivanova T.V., Miloslavsky Yu.V.
Subjects and methods. The investigation enrolled 145 patients aged 25–42 years with an established diagnosis of infertility and a history of superovulation using GnRH agonists and antagonists. Group 1 included 65 patients who had undergone a surgery on the ovaries and received no pregravid preparation; Group 2 consisted of 60 patients who had a surgery on the ovaries and pregravid preparation for assisted reproductive technology (ART) programs during 2-3 months as the complex Pregnoton in combination with hormone therapy. The comparison group comprised 20 patients with intact ovaries and tuboperitoneal factor infertility. The investigation was conducted within the preparation of patients for an assisted reproductive technology protocol.
Results. After implementing the ART protocol, pregnancy occurred in 15.5, 31.7, and 35% of cases in Groups 1, 2, and 3, respectively.
Conclusion. Comprehensive pregravid preparation, including the complex Pregnoton in combination with hormonal therapy, makes it possible not only to increase the rate of pregnancy, but also to lower a risk for pregnancy complications, and thus affecting perinatal and infant losses.
Keywords
infertility
pregravid preparation
pregnancy
Pregnoton
transdermal 17β-estradiol (Divigel)
Supplementary Materials
- Table 1. Operative treatment in different groups of our investigation, n (%)
- Table 2. Analysis of the ovarian reserve before the IVF, M±m
- Table 3. The thickness of the endometrium of ultrasound investigation in different periods of the menstrual cycle, M±m
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Received 16.12.2016
Accepted 23.12.2016
About the Authors
Serebrennikova Klara Georgievna, MD, professor, I.M. Sechenov 1st Moscow State Medical University; Scientific adviser on obstetrics and gynecologyat the Central Clinical Hospital of the Russian Academy of Sciences. 117593, Russia, Moscow, Lithuanian Boulevard, 1A. E-mail: klaraserebrennikova@mail.ru
Kuznetsova Elena Petrovna, MD, associate professor, chief freelance specialist of the Ministry of Health of the Udmurt Republic for reproduction,
head of the ECO Center and reproductions of The first republican clinical hospital, Ministry of Health of the Udmurt Republic.
426000, Russia, Izhevsk, Votkinskoye Highway, 57. E-mail: doctorfamily@mail.ru
Ivanova Tatyana Vitalievna, embryologist of the department of the ART, Central Clinical Hospital of the Russian Academy of Sciences.
117593, Russia, Moscow, Lithuanian Boulevard, 1A. E-mail: embryodoc@mail.ru
Vanke Ekaterina Sergeevna, obstetrician-gynecologist of the gynecological department of the Central Clinical Hospital of the Russian Academy of Sciences.
117593, Russia, Moscow, Lithuanian Boulevard, 1A. E-mail: vanke_katy@mail.ru
Miloslavsky Yuri Viktorovich, obstetrician-gynecologist of the gynecological department of the Central Clinical Hospital of the Russian Academy of Sciences.
117593, Russia, Moscow, Lithuanian Boulevard, 1A. E-mail: md_miloslavsky@mail.ru
For citations: Serebrennikova K.G., Kuznetsova E.P., Vanke E.S., Ivanova T.V., Miloslavsky Yu.V. Pregravid preparation in patients with the thin endometrium in assisted reproductive technology programs. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (3): 139-46. (in Russian)
http://dx.doi.org/10.18565/aig.2017.3.139-46
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