Search for prognostic markers of the course of endometriosis
Endometriosis is regarded as one of the most urgent problems of modern gynecology, whereas its prevalence is about 10% (190 million females) of all reproductive-aged women worldwide. Despite the benign nature of this disease, this process has the features similar to those of malignant diseases, such as loss of cell proliferation control, a tendency for invasive growth, an elevated blood level of cancer-specific markers, and a propensity to relapse.The paper reviews the literature data by Russian and foreign authors, which have been published in the Cochrane Library, Pubmed, and eLibrary databases on the role of the following biomarkers: acetylcholine receptors, matrix metalloproteinases, paraoxonases, bradykinin receptors, and estradiol receptors, in the context of evaluating the course of endometriosis. The increasing role of this disease in the pattern of gynecological diseases, the social significance of the problem, long diagnostic periods, and treatment start since the first symptoms appear generate a need for the medical community to conduct a comprehensive study of this pathology.Levakov S.A., Pertseva Yu.A., Obukhova E.A., Paukov S.V., Bondarenko N.L., Shakhparonov M.I., Antipova N.V.
Conclusion: Further in-depth study and clarification of the etiopathogenetic mechanisms of endometriosis, as well as the creation of new diagnostic models, will be able to more successfully apply and/or to combine various procedures and methods for treating this disease, developing a modern concept of epigenetic rehabilitation, and improving quality of life in these patients.
Authors’ contributions: Levakov S.A. – idea of the article, search for and analysis of the data available in the literature;
Pertseva Yu.A., Obukhova E.A., Paukov S.V. – search for publications on the topic of the review, analysis and translation of foreign literature, writing the text; Bondarenko N.L., Shakhparonov M.I., Antipova N.V. – editing the text.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has been conducted under Russian Science Foundation Grant “Investigation of the role of cys-loop receptors in the interactions of glioblastoma cells with their microenvironment” under No. 21-74-10092.
For citation: Levakov S.A., Pertseva Yu.A., Obukhova E.A., Paukov S.V., Bondarenko N.L., Shakhparonov M.I., Antipova N.V. Search for prognostic markers of the course of endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (2): 32-36 (in Russian)
https://dx.doi.org/10.18565/aig.2022.262
Keywords
endometriosis
endometrioid cystadenoma
acetylcholine receptors
biomarkers
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Received 04.11.2022
Accepted 16.01.2023
About the Authors
Sergey A. Levakov, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First MSMU, Ministry of Health of Russia (Sechenov University), levakov_s_a@staff.sechenov.ru, 8-2 Trubetskaya str., Moscow, 119991, Russia.Yulia A. Pertseva, postgraduate student, Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First MSMU,
Ministry of Health of Russia (Sechenov University), yurchenko_yulya@mail.ru, 8-2 Trubetskaya str., Moscow, 119991, Russia.
Elizaveta A. Obukhova, Assistant, Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First MSMU,
Ministry of Health of Russia (Sechenov University), liza_obukhova@mail.ru, 8-2 Trubetskaya str., Moscow, 119991, Russia.
Sergey V. Paukov, PhD, Associate Professor, Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First MSMU,
Ministry of Health of Russia (Sechenov University), paukov_s_v@staff.sechenov.ru, 8-2 Trubetskaya str., Moscow, 119991, Russia.
Natalia L. Bondarenko, PhD, Chief Physician, Clinical Hospital No. 85, Federal Medical and Biological Agency of Russia, 16 Moskvorechye str., Moscow, 115409, Russia.
Mikhail I. Shakhparonov, PhD in Chemistry, Leading Researcher at the Laboratory of Membrane and Bioenergetic Systems, M.M. Shemyakin and Yu.A. Ovchinnikov Institute
of Bioorganic Chemistry RAS, shakhparonov@gmail.com, https://orcid.org/0000-0001-5965-8067, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
Nadezhda V. Antipova, PhD, Senior Researcher at the Laboratory of Membrane and Bioenergetic Systems, M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry RAS; Associate Professor, Department of Pharmaceutical and Toxicological Chemistry, RUDN University, Nadine.antipova@gmail.com,
16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
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