Long-term outcomes of hypertensive disorders of pregnancy

Dolgushina V.F., Syundyukova E.G., Chulkov V.S., Ryabikina M.G.

South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia
The article reviews Russian and international literature published within the past five years on the relationship between hypertensive disorders of pregnancy and the risk of future chronic non-communicable diseases, including cardiovascular, cerebrovascular, chronic kidney diseases, and metabolic disorders. The review findings suggest that a history of hypertensive disorders of pregnancy confers a significant increase in the risk for chronic non-communicable diseases later in life. The authors identified a dose-dependent effect of early, severe, and recurrent preeclampsia on timing and the severity of chronic conditions and multimorbidity. This association somewhat weakens after adjustment for traditional risk factors (maternal age, smoking, family history of preeclampsia, obesity, hypertension, diabetes). However, underlying mechanisms for chronic non-communicable diseases after preeclampsia remain unclear. Besides, no regulatory documents define diagnostic, therapeutic, preventive measures for the rehabilitation of women with a history of preeclampsia. Clinical trials are required to validate primary and secondary prevention strategies for chronic somatic conditions in this population.
Conclusion: The review has underscored a need for continuity and professional cooperation of obstetric and internal medicine communities to develop interdisciplinary recommendations to minimize the risks of developing future chronic non-communicable diseases.


hypertensive disorders of pregnancy
chronic non-communicable diseases


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Received 14.07.2021

Accepted 27.07.2021

About the Authors

Valentina F. Dolgushina, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, South Ural State Medical University, Ministry of Health of the Russian Federation, +7(919)329-32-45, dolgushinavf@yandex.ru, 454091, Russia, Chelyabinsk, Vorovsky str., 64.
Elena G. Syundyukova, Dr. Med. Sci., Associate Professor, Professor of the Department of Obstetrics and Gynecology, South Ural State Medical University, Ministry of Health of the Russian Federation, +7(351)721-46-32, +7(900)027-08-82, seg269@mail.ru, 454091, Russia, Chelyabinsk, Vorovsky str., 64.
Vasiliy S. Chulkov, Dr. Med. Sci., Associate Professor, Professor of the Department of Faculty Therapy, South Ural State Medical University, Ministry of Health of the Russian Federation, +7(351)253-69-11, +7(922)698-2-328, vschulkov@rambler.ru, 454091, Russia, Chelyabinsk, Vorovsky str., 64.
Marya G. Ryabikina, doctor of the Department of Pathology of Pregnancy, Clinic of the South Ural State Medical University, Ministry of Health of the Russian Federation, +7(351)721-46-32, +7(919)311-2-488, mryabikina@mail.ru, 454091, Russia, Chelyabinsk, Cherkasskaya str., 2.

Authors' contributions: Dolgushina V.F., Syundyukova E.G. – conception and design of the study; Syundyukova E.G., Chulkov V.S. – data collection and analysis; Syundyukova E.G., Chulkov V.S., Ryabikina M.G. – manuscript drafting; Dolgushina V.F. – manuscript editing.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: There was no funding for this study.
For citation: Dolgushina V.F., Syundyukova E.G., Chulkov V.S., Ryabikina M.G. Long-term outcomes of hypertensive disorders of pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021;10: 14-20 (in Russian)

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