Characteristics of the level of soluble form of receptor for glycation end products in very early threatened preterm labor
Objective. To identify the characteristics of the level of a soluble form of receptors for advanced glycation end products (sRAGE) in women with threatened preterm labor (TPL) at 22-27 weeks’ gestation in relation to the outcome of pregnancy and perinatal pathology.Smirnova A.V., Borzova N.Yu., Sotnikova N.Yu., Malyshkina A.I.
Material and methods. Enzyme immunoassay was used to determine the venous serum levels of sRAGE and antibodies to the causative agents of major infections.
Results. Reduced sRAGE levels were characteristic of pregnant women with TPL at 22-27 weeks, which culminated in premature birth (PB), as compared with those with uncomplicated pregnancy and TPL that ended in full-term birth. The patients with TRL, who gave birth to babies with perinatal hypoxic lesions (PHL) of the central nervous system (CNS), showed a more pronounced decrease in sRAGE levels.
Conclusion. PB in women with TPL at 22-27 weeks was associated with a reduction in sRAGE levels. The low content of sRAGE in those with TPL at 22-27 weeks is a predictor for the development of PHL of the CNS.
Keywords
threatened preterm labor
receptor for glycosylation end products
perinatal hypoxic lesions of the central nervous system
References
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Received 08.02.2017
Accepted 17.02.2017
About the Authors
Smirnova Anastasia Vladimirovna, Ph.D., Assistant of the Department of Obstetrics and Gynecology, Medical Genetics, Ivanovo State Medical Academy,Ministry of Health of Russia. 153000, Russia, Ivanovo, Sheremetevsky prospect, 8. Tel.: +79203443830. E-mail: anguseva@yandex.ru
Borzova Nadezhda Yurievna, MD, professor, chief research officer of the Department of Obstetrics and Gynecology, V.N. Gorodkov Ivanovo Research Institute
of Maternity and Childhood, Ministry of Health of Russia. 153045, Russia, Ivanovo, Pobedy str. 20. Tel.: +74932351609. E-mail: borzova__n@mail.ru
Sotnikova Natalia Yurievna, MD, professor, head of the Laboratory of Clinical Immunology, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood,
Ministry of Health of Russia; professor of the Department of Pathophysiology, Clinical Pathophysiology and Immunology, Ivanovo State Medical Academy, Ministry of Health of Russia. Address: 153045, Russia, Ivanovo, Pobedy str. 20 Tel.: +74932336928. E-mail: niimid.immune@mail.ru
Malyshkina Anna Ivanovna, MD, director of V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia;
Head of the Department of Obstetrics and Gynecology Ivanovo State Medical Academy, Ministry of Health of Russia.
Address: 153045, Russia, Ivanovo, Pobedy str. 20 Tel.: +74932351609
For citations: Smirnova A.V., Borzova N.Yu., Sotnikova N.Yu., Malyshkina A.I. Characteristics of the level of soluble form of receptor for glycation end products in very early threatened preterm labor. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (10): 35-9. (in Russian)
https://dx.doi.org/10.18565/aig.2017.10.35-39
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