Role of the receptor for advanced glycation end products (RAGE) and its ligands in human reproduction

DOI

https://dx.doi.org/10.18565/aig.2020.7.20-26

Smirnova A.V., Borzova N.Yu., Malyshkina A.I., Sotnikova N.Yu.
1) Ivanovo State Medical University, Ministry of Health of Russia, Ivanovo, Russia; 2) V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia, Ivanovo, Russia

Studying the components of the immune system in reproductive disorders allows a better understanding of the causes of infertility, in vitro fertilization (IVF) failure, pregnancy complications, and adverse perinatal outcomes. RAGE (receptor for advanced glycation end products) and its ligands are one of the important components of innate and adaptive immunity. This receptor is largely expressed on the membranes of alveolocytes, myocytes, endotheliocytes, immune and embryonic cells, and glial cells. High RAGE expression is associated with a variety of diseases, the pathogenesis of which is dominated by chronic stress, inflammation, or necrosis, such as diabetes mellitus, rheumatoid arthritis, and hypertension. The review analyzes data on changes in RAGE and its ligands in female and male infertility, polycystic ovary syndrome, and obesity. The paper gives clinical and fundamental studies on the levels of sRAGE in patients with diminished ovarian reserve in IVF programs and considers its possible role in the pathogenesis of reproductive aging. It also discusses in detail the role of RAGE and its main ligands during uncomplicated pregnancy, its dynamic changes in the trimester of pregnancy, and its relationship to the development of “the great obstetric syndromes”, such as threatened miscarriage and preeclampsia. Special attention is paid to the role of this receptor and its ligands in the pathogenesis of perinatal pathology in newborns, and new methods of antenatal prediction of perinatal hypoxic damage to the central nervous system are proposed. Studying RAGE and its ligands may open up new possibilities for the therapeutic use of sRAGE to prevent the damaging effects of glycation products.

receptor for advanced glycation end products

RAGE

infertility

threatened preterm labor

preeclampsia

perinatal pathology

Full text (in Russian)

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Received 03.03.2020

Accepted 15.06.2020

Anastasiia V. Smirnova, k. m. n., docent of Department obstetrics and gynecology, medical genetics, FSBEI HE IvSMA MOН Russia. Tel.: +7(920)344-38-30.
E-mail: anguseva@yandex.ru. ORCID: 0000-0002-6811-6830, eLibrary SPIN: 1871-4605.
153000, Russia, Ivanovo, Sheremetevskii prospect, 8.
Nadezhda Yu. Borzova, MD, PhD, Dr. Med. Sci., main scientist, Department of obstetrics and gynecology, Federal State Budget Institute Ivanovo Scientific-research Institute named after V.N. Gorodkov, MOH, Russia, Ivanovo. Tel.: +7(4932)35-16-09. E-mail: borzova__n@mail.ru. ORCID: 0000-0002-2247-3963.
153045, Russia, Ivanovo, Pobedy str., 20.
Anna I. Malyshkina, MD, PhD, Dr. Med. Sci., director Federal State Budget Institute Ivanovo Scientific-research Institute named after V.N. Gorodkov, MOH Russia, Ivanovo. Тел.: +7(4932)35-16-09. ORCID: 0000-0002-1145-0563.
153045, Russia, Ivanovo, Pobedy str., 20; 153000, Russia, Ivanovo, Sheremetevskii prospect, 8.
Natalia Yu. Sotnikova, MD, PhD, Dr. Med. Sci., Head of laboratory of clinical immunology, Federal State Budget Institute Ivanovo Scientific-research Institute named
after V.N. Gorodkov, MOH Russia, Ivanovo. Тел.: +7(4932)33-69-28. E-mail: niimid.immune@mail.ru. ORCID: 0000-0002-0608-0692.
153045, Russia, Ivanovo, Pobedy str., 20; 153000, Russia, Ivanovo, Sheremetevskii prospect, 8.

For citation: Smirnova A.V., Borzova N.Yu., Malyshkina A.I., Sotnikova N.Yu. Role of the receptor for advanced glycation end products (RAGE) and its ligands in human reproduction.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 7: 20-26 (in Russian).
https://dx.doi.org/10.18565/aig.2020.7.20-26

Role of the receptor for advanced glycation end products (RAGE) and its ligands in human reproduction

Smirnova A.V., Borzova N.Yu., Malyshkina A.I., Sotnikova N.Yu.

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