Serum levels of growth factors (PlGF, PDGF-BB, VEGF-A) in women with infertility and miscarriage associated with chronic endometritis
Objective. To justify the diagnostic and prognostic value of the serum levels of placental growth factor (PlGF), platelet-derived growth factor (PDGF-BB), and vascular endothelial growth factor (VEGF-A) in women with infertility and/or miscarriage due to chronic endometritis.Kometova V.V., Kozyreva E.V., Davidyan L.Yu., Malanina E.N., Bogdasarov A.Yu., Voznesenskaya N.V.
Subjects and methods. A comprehensive examination was made in 88 women who were divided into the following clinical groups: 1) 28 women with recurrent pregnancy loss and morphologically and immunohistochemically confirmed chronic endometritis; 2) 36 infertile patients with chronic endometritis; 3) 24 women with male factor infertility and unchanged endometrial structure (a control group).
The investigators performed clinical (history data collection, general and gynecological examinations) and ultrasound studies on days 15-22 of the menstrual cycle, aspiration and Pipelle biopsies of the endometrium on days 7-11 of the menstrual cycle, and enzyme immunoassay of serum PlGF, PDGF-BB, and VEGF-A levels.
Results. PlGF and VEGF were increased and PDGF-BB was decreased in the serum of the women in Groups 1 and 2.
Conclusion. The above results can be used in clinical practice. The determination of PIGF and VEGF-A levels is one of the promising methods for evaluating the endometrium.
Keywords
infertility
miscarriage
chronic endometritis
immunohistochemical examination
placental growth factor (PlGF)
platelet-derived growth factor (PDGF-BB)
vascular endothelial growth factor (VEGF-A)
References
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Received 28.06.2016
Accepted 02.09.2016
About the Authors
Kоmetova Vlada Vladimirovna, PhD, senior researcher, Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of Russia.117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79051837783. E-mail: vladastasiatema@mail.ru
Kozyreva Elena Vladimirovna, PhD, obstetrician-gynecologist, Ulyanovsk Regional Clinical Hospital.
432017, Russia, Ulyanovsk, Tretyego Internatsionala str. 7. Tel.: +79272702338. E-mail: miss_smile_777@mail.ru
Davidian Liana Yuryevna, MD, professor of the Faculty of postgraduate medical and pharmaceutical education, Ulyanovsk State University.
432017, Russia, Ulyanovsk, Lva Tolstogo str. 42. Tel.: +79276314968. E-mail: a.bogdasarov@mail.ru
Malanina Ekaterina Nikolaevna, PhD, doctor of ultrasonic diagnostics, Ulyanovsk Regional Clinical Hospital.
432017, Russia, Ulyanovsk, Tretyego Internatsionala str. 7. Tel.: +79278093382. E-mail: malaninaekaterina@mail.ru
Bogdasarov Azat Urievich, MD, professor, chief physician of the medical center „My doctor”,
432017, Russia, Ulyanovsk, 2-y pereulok Mira 24. Tel.: +79278154708. E-mail: a.bogdasarov@mail.ru
Voznesenskaia Nadezhda Vadimovna, PhD, assistant professor, Department of Obstetrics and Gynecology, Ulyanovsk State University.
432017, Russia, Ulyanovsk, Lva Tolstogo str. 42. Tel.: +79278053841. E-mail: vnadezda@list.ru
For citations: Kometova V.V., Kozyreva E.V., Davidyan L.Yu., Malanina E.N., Bogdasarov A.Yu., Voznesenskaya N.V. Serum levels of growth factors (PlGF, PDGF-BB, VEGF-A) in women with infertility and miscarriage associated with chronic endometritis. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (4): 74-80. (in Russian)
http://dx.doi.org/10.18565/aig.2017.4.74-80
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