Features of micronutrient preparation for pregnancy in women with polycystic ovary syndrome

Kuznetsova I.V., Gavrilova E.A.

1) Higher Medical School, Moscow, Russia; 2) N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia
Objective. To carry out a systems analysis of the data available in the literature on the methods of micronutrient preparation for pregnancy in patients with polycystic ovary syndrome (PCOS).
Material and methods. To carry out the analysis, foreign and Russian publications published in the past 15 years were sought in the international citation system Pubmed.
Results. The investigators considered the pathophysiological mechanisms for reducing fertility in PCOS, including those associated with micronutrient deficiency and presented data on the benefits of taking vitamins, minerals, and other biologically active substances to increase fertility and to reduce the risk of gestational complications in patients with PCOS. They also analyzed the results of clinical trials, which showed the effectiveness of using myo-inositol, folic acid, antioxidants, and other biologically active substances in women with PCOS during pregravid preparation. The data given provide evidence that the intake of micronutrients is necessary for PCOS patients during preparation for pregnancy.


polycystic ovary syndrome
active biological food supplement
vitamin-mineral complexes
pregravid preparation


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Received 08.05.2020

Accepted 29.05.20

About the Authors

Irina V. Kuznetsova, professor, Head of gynecological endocrinology research unit, Higher Medical School. Tel.: +7 (495) 212-23-56. E-mail: ms.smith.ivk@gmail.com.
3A–2 Malaya Semenovskaya str., Moscow, 105318, Russian Federation.
Ekaterina A. Gavrilova, graduate student, Department of obstetrics and gynecology in the Institute of Clinical Medicine, Sechenov University.
Tel.: +7 (499) 248-66-07. E-mail: gavrilova263@yandex.ru.
2–1 Elanskogo str., Moscow, 119435, Russian Federation.

For reference: Kuznetsova I.V., Gavrilova E.A. Features of micronutrient preparation for pregnancy in women with polycystic ovary syndrome
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 6: 116-122 (in Russian)

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