The specific features of vaginal and intestinal microbiota in women of North indigenous smallnumbered peoples under the conditions of the urbanized North
Objective. To study of the biocenosis of the vagina and gastrointestinal tract, weight and growth parameters in the North indigenous small-numbered peoples (NISMP), who have migrated and live in the city of Khanty-Mansiysk, Khanty-Mansi Autonomous Okrug–Yugra.Solovyeva A.V., Chegus L.A.
Subjects and methods. Complaints and anamnestic and anthropometric data were prospectively analyzed; as well as the vaginal and intestinal biocenosis was evaluated in 125 patients selected using the continuous sampling method. Examinations were made in the women of the indigenous minorities of the Khanty and Mansi, who lived in the urban community Berezovo, in nomad camps, and in Khanty-Mansiysk. The comparison group included female newcomers (Russians, Ukrainians, Tatars, Bashkirs, and others) living in Khanty-Mansiysk. Microbiological examination of vaginal discharge included microscopy of Gram stained smears and real-time PCR (Femoflor). The intestinal microbiota was investigated by real-time PCR (Colonoflor).
Statistical processing was performed using the SPSS, Statistica 8.0 software package, as well as the Microsoft Exsel analysis package.
Results. The smallest number of deviations in health status was seen in the women of the NISMP, who lived in the rural areas and nomad camps and led a traditional nomadic lifestyle. The deficit of body weight was observed in 10.3% of the women; obese patients were absent in this group. Analysis of the microbiota of vaginal discharge showed that normocenosis was in the majority (87.2%) of the women. No substantial changes were found in the gut microbiota.
The urban residents, both newcomers and NISMP, had the greatest number of abnormalities in the biocenosis of the vagina and large bowel. They had frequently combined disorders: bacterial vaginosis and vulvovaginal candidiasis.
Conclusion. This makes it possible to recommend Clindacin B prolong (Akrikhin Co., Russia), a combination of clindamycin phosphate, a broad spectrum antibiotic, and butoconazole, an antimycotic from a group of azoles, for treatment. The drug is effective for clinical recovery in a set of inflammatory and non-inflammatory changes in the vagina with vulvovaginal candidiasis.
Keywords
urbanization of North indigenous peoples
vaginal and intestinal microbiota
vaginal biocenotic disorders
Clindacin B prolong
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Received 06.10.2020
Accepted 29.10.2020
About the Authors
Alina V. Solovyeva, Doctor of medicine, professor of the Department of obstetrics and gynecology with the course of perinatology, Peoples’ Friendship University of Russia (RUDN University). Tel.: +7(985)447-79-28. E-mail: av_soloveva@mail.ru. ORCID: 0000-0001-6711-1563. 117198, Russia, Moscow, Miklukho-Maklaya str., 8.Larisa A. Chegus, PhD in medicine, associate Professor, Department of obstetrics and gynecology, Khanty-Mansi State Medical Academy.
E-mail: lchegus@mail.ru. ORCID: 0000-0002-9698-8038. 628011, Russian Federation, Khanty-Mansiysk, Yamskaya str., 12/91
For citation: Solovyeva A.V., Chegus L.A. The specific features of vaginal and intestinal microbiota in women of North indigenous small-numbered peoples under the conditions of the urbanized North.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 11: 174-182 (in Russian).
https://dx.doi.org/10.18565/aig.2020.11.174-182
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