Experience with different cholecalciferol dosing regimens to achieve adequate levels in patients with reproductive dysfunction
Objective. To study the time course of changes in the serum level of 25(OH)D in the use of different doses of cholecalciferol as chewable tablets dispersed in the mouth (the dietary supplement (DS) Ultra-D Vitamin D3).Chikh E.V., Tikhomirov S.V., Zaitseva T.A., Segedina E.M., Treivish L.S.
Subjects and methods. A total of 125 reproductive-aged patients took cholecalciferol as chewable tablets dispersed in the mouth (DS Ultra-D Vitamin D3). Groups 1, 2, and 3 received DS Ultra-D Vitamin D3 in daily doses of 4.000, 5.000, and 6.000 IU, respectively. The use duration was 8 weeks. 25(OH)D was determined by a chemiluminescent microparticle immunoassay.
Results. When the chewable tablets were used in a daily dose of 4.000 IU, the vitamin D levels above 30 ng/ml were achieved in 100% of patients; M ± s 45.75 ± 7.84 ng/ml; the dynamics was 123 Δ%. When the chewable tablets were given in daily dose of 5.000 and 6.000 IU, the vitamin D level above 30 ng/ml was achieved in 93.5 and 96.8% of the patients, respectively; its mean concentrations for the group were 36.86 ± 6.03 and
40.64 ± 4.95 ng/ml, respectively; the dynamics was 103 and 116.5 Δ%.
Conclusion. The 8-week use of cholecalciferol at a daily dose of 4,000 IU as chewable tablets dispersed in the mouth is sufficient to achieve an adequate vitamin D level.
Keywords
vitamin D
adequate level
dose
chewable tablets
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Received 18.02.2019
Accepted 22.02.2019
About the Authors
Chikh, Evgenia V., MD, professor, head of Department of Clinical Pharmacology and Propedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74956091991. E-mail: chih@mail.ruTikhomirov, Sergey V., urologist, doctor of the highest category, head of Medical Centr «Ecopark».
630032, Novosibirsk, Gorsky prospect str. 6. Tel.: +73833080006. E-mail: mcecopark@ya.ru
Zaitseva, Tatiana A., Endicrynolodist, Sexologist of the highest category, Krasnoyarsky Centr of Reproductive Medicine, Group of company «Mother and child».
660135, Russia, Krasnoyarsk, Vsletnaya str. 1. Tel.: +73912699763. E-mail: t.zaytseva@mcclinic.s.ru
Segedina, Evgenia M., Gynecologist-endocrinologist oh first category, Medical Center «Serdolik».
630117, Russia, Novosibirsk, Arbuzova str. 1. Tel.: +73833734849. E-mail: evgmix@rambler.ru
Treivish, Lubov S., PhD, Gynecologist of the highest category, Chief of policlinic Obstetric-Gynecological department Medical Centre «Avitsenna» Group of company
«Mother and child». 630091, Russia, Novosibitsk, Krasniy prospekt 14, bldg. 1. Tel.: +73833633003. E-mail: ms.lubov_tr@mail.ru
For citations: Chikh E.V., Tikhomirov S.V., Zaitseva T.A., Segedina E.M., Treivish L.S. Experience with different cholecalciferol dosing regimens to achieve adequate levels in patients with reproductive dysfunction. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): 143-7. (in Russian)
http://dx.doi.org/10.18565/aig.2019.2.143-147
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