Experience with different cholecalciferol dosing regimens to achieve adequate levels in patients with reproductive dysfunction

Chikh E.V., Tikhomirov S.V., Zaitseva T.A., Segedina E.M., Treivish L.S.

1 I.M. Sechenov First Moscow State Medical University (Sechenov University); 2 Ecopark Medical Center, Novosibirsk, Russia; 3 Mother and Baby Group Companies, Krasnoyarsk Center for Reproductive Medicine, Krasnoyarsk, Russia; 4 Serdolik (Carnelian) Medical Center, Novosibirsk, Russia; 5 Mother and Baby Group Companies, AO “Avicenna” Medical Center, Novosibirsk, Russia;
Objective. To study the time course of changes in the serum level of 25(OH)D in the use of different doses of cholecalciferol as chewable tablets dispersed in the mouth (the dietary supplement (DS) Ultra-D Vitamin D3).
Subjects and methods. A total of 125 reproductive-aged patients took cholecalciferol as chewable tablets dispersed in the mouth (DS Ultra-D Vitamin D3). Groups 1, 2, and 3 received DS Ultra-D Vitamin D3 in daily doses of 4.000, 5.000, and 6.000 IU, respectively. The use duration was 8 weeks. 25(OH)D was determined by a chemiluminescent microparticle immunoassay.
Results. When the chewable tablets were used in a daily dose of 4.000 IU, the vitamin D levels above 30 ng/ml were achieved in 100% of patients; M ± s 45.75 ± 7.84 ng/ml; the dynamics was 123 Δ%. When the chewable tablets were given in daily dose of 5.000 and 6.000 IU, the vitamin D level above 30 ng/ml was achieved in 93.5 and 96.8% of the patients, respectively; its mean concentrations for the group were 36.86 ± 6.03 and
40.64 ± 4.95 ng/ml, respectively; the dynamics was 103 and 116.5 Δ%.
Conclusion. The 8-week use of cholecalciferol at a daily dose of 4,000 IU as chewable tablets dispersed in the mouth is sufficient to achieve an adequate vitamin D level.


vitamin D
adequate level
chewable tablets


  1. Colonese F., Laganà A.S., Colonese E., Sofo V., Salmeri F.M., Granese R. et al. The pleiotropic effects of vitamin D in gynaecologicaland obstetric diseases: an overview on a hot topic. Biomed. Res. Int. 2015; 2015: 986281. https://dx.doi.org/10.1155/2015/986281.
  2. Al-Jaroudi D., Al-Banyan N., Aljohani N.J., Kaddour O., Al-Tannir M. Vitamin D deficiency among subfertile women: case-control study. Gynecol. Endocrinol. 2016; 32(4): 272-5. https://dx.doi.org/10.3109/09513590.2015.1112784.
  3. Garbedian K., Boggild M., Moody J., Liu K.E. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open. 2013; 1(2): e E77-82. https://dx.doi.org/10.9778/cmajo.20120032.
  4. Зазерская И.Е., ред. Витамин D и репродуктивное здоровье женщины. СПб.: Эко-Вектор; 2017. 151с. [Zazerskaya I.E., ed. Vitamin D and female reproductive health. SPb .: Eco-Vector; 2017. 151p. (in Russian)]
  5. Громова О.А., Торшин И.Ю., Джиджихия Л.К., Гоголева И.В. Роль витамина D в профилактике и лечении женского бесплодия. Гинекология. 2016; 18(3): 34-9. [Gromova O.A., Torshin I.Yu., Jijiha LK, Gogoleva I.V. The role of vitamin D in the prevention and treatment of female infertility. Gynecology. 2016; 18 (3): 34-9. (in Russian)]
  6. Irani M., Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil. Steril. 2014; 102(2): 460-8. e3.
  7. Umme Hani Abdullah, Salima Lalani, Fatima Syed, Sara Arif & Rehana Rehman. Association of Vitamin D with outcome after intra cytoplasmic sperm injection. J. Matern. Fetal Neonatal Med. 2017; 30(1): 117-20.
  8. Carter G.D., Phinney K.W. Assessing Vitamin D status: time for a rethink? Clin. Chem. 2014; 60(6): 809-11.
  9. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., Дзеранова Л.К., Каронова Т.Л., Ильин А.В., Мельниченко Г.А., Дедов И.И. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016; 62(4): 60-84. [Pigarova E.A., Rozhinskaya L.Ya., Belaya Z.E., Dzeranova L.K., Karonova T.L., Ilyin A.V., Melnichenko G.A., Dedov I.I. Clinical recommendations of the Russian Association of Endocrinologists on the diagnosis, treatment and prevention of vitamin D deficiency in adults. Endocrinology problems. 2016; 62 (4): 60-84.(in Russian)]
  10. Thorne-Lyman A., Fawzi W.W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr. Perinat. Epidemiol. 2012; 26 (Suppl.1): 75-90. doi:10.1111/j.1365-3016.2012.01283.x.
  11. Громова О.А. Особенности фармакологии водорастворимой формы витамина D на основе мицелл. Практика педиатра. 2014; 12: 31-7. [Gromova O.A. Features of pharmacology of water-soluble form of vitamin D on the basis of micelles. Practice pediatrician. 2014; 12: 31-7. (in Russian)]

Received 18.02.2019

Accepted 22.02.2019

About the Authors

Chikh, Evgenia V., MD, professor, head of Department of Clinical Pharmacology and Propedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74956091991. E-mail: chih@mail.ru
Tikhomirov, Sergey V., urologist, doctor of the highest category, head of Medical Centr «Ecopark».
630032, Novosibirsk, Gorsky prospect str. 6. Tel.: +73833080006. E-mail: mcecopark@ya.ru
Zaitseva, Tatiana A., Endicrynolodist, Sexologist of the highest category, Krasnoyarsky Centr of Reproductive Medicine, Group of company «Mother and child».
660135, Russia, Krasnoyarsk, Vsletnaya str. 1. Tel.: +73912699763. E-mail: t.zaytseva@mcclinic.s.ru
Segedina, Evgenia M., Gynecologist-endocrinologist oh first category, Medical Center «Serdolik».
630117, Russia, Novosibirsk, Arbuzova str. 1. Tel.: +73833734849. E-mail: evgmix@rambler.ru
Treivish, Lubov S., PhD, Gynecologist of the highest category, Chief of policlinic Obstetric-Gynecological department Medical Centre «Avitsenna» Group of company
«Mother and child». 630091, Russia, Novosibitsk, Krasniy prospekt 14, bldg. 1. Tel.: +73833633003. E-mail: ms.lubov_tr@mail.ru

For citations: Chikh E.V., Tikhomirov S.V., Zaitseva T.A., Segedina E.M., Treivish L.S. Experience with different cholecalciferol dosing regimens to achieve adequate levels in patients with reproductive dysfunction. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): 143-7. (in Russian)

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