Therapeutic and prophylactic effects of vitamin D in gynecological diseases associated with excessive proliferation
Objective. To carry out a systems analysis of the data available in the current literature on the impact of vitamin D deficiency on the risk of endometriosis and reproductive cancer, as well as on the possibilities of vitamin D supplementation in order to treat and prevent these diseases.Kuznetsova I.V.
Material and methods. The review includes the data of foreign and Russian articles published in the past 10 years and found in Pubmed on this topic.
Results. The paper describes the mechanisms by which vitamin D is involved in the processes of inflammation, immunomodulation, and proliferation, as well as the role of its deficiency in pathogenesis of pathological proliferation and inflammation in endometriosis, breast cancer, and ovarian cancer. It gives the data of clinical trials confirming the role of vitamin D deficiency in the progression and negative effects of endometriosis and carcinogenesis, the possibility of vitamin D supplementation for the prevention and adjunct therapy of reproductive cancer and endometriosis.
Conclusion. It is necessary to conduct further studies to experimentally and clinically evaluate vitamin D deficiency in endometriosis and cancer. Currently, vitamin D supplements should be prescribed to patients with this pathology if they have been found to have a low blood level of 25(OH)D3.
Keywords
vitamin D
cholecalciferol
calcidiol
calcitriol
endometriosis
breast cancer
ovarian cancer
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Received 16.02.2018
Accepted 02.03.2018
About the Authors
Irina Vsevolodovna Kuznetsova, MD, professor of the Department of Obstetrics and Gynecology No. 1, Therapeutic Faculty, I.M. Sechenov First Moscow State Medical University. 119992, Russia, Moscow, Malaya Trubetskaya str. 8, bld. 2For citations: Kuznetsova I.V. Therapeutic and prophylactic effects of vitamin D in gynecological diseases associated with excessive proliferation. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (4): 138-43. (in Russian)
https://dx.doi.org/10.18565/aig.2018.4.138-143
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