Experience with sanitary products containing the probiotic strain Lactobacillus acidophilus in reproductive-aged and postmenopausal women for the prevention of opportunistic vaginal infections

Lyubasovskaya L.A., Melkumyan A.R., Dubodelov D.V., Rodchenko Yu.V., Muravyeva V.V., Kondrakhin A.P., Maikova G.B., Amirkhanyan A.S., Nikolaeva N.V., Bairamova G.R., Priputnevich T.V.

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia

Objective. To obtain data on the efficiency of preventive use of hygiene products (sanitary pads containing the probiotic strain Lactobacillus acidophilus in women suffering from recurrent vaginal infections caused by opportunistic microorganisms, by estimating the frequency of exacerbations of the chronic process and the changes in the titer of Lactobacilli during the two parallel-group study.
Subjects and methods. The investigation was conducted in two age- and menstrual cycle-matched female groups (a study group included women who used probiotic-containing sanitary pads and a control group consisted of those who did not apply probiotic-containing sanitary pads). The duration of each woman’s participation in the study was three months. Vaginal microcenosis in the absence of a recurrence during the study was investigated at two points: before and three months after the study through culture medium inoculation and microscopy of Gram-stained vaginal smears. When relapses of the chronic process occurred during the study, additional microbiological testing for recurrent opportunistic vaginal infection was performed.
Results. This pilot study showed an apparent, but statistically insignificant decline in the number of recurrent opportunistic vaginal infections and an increase in the Lactobacillus titer in the vaginal discharge of women who regularly applied probiotic-containing pads. The group of women using probiotic-containing sanitary pads had a recurrence rate that was twice as low as in the control group (22.5% versus 50%). The normal microscopic pattern was more frequently observed in the study group (92.5%) than in the control group (65%). The study group showed a higher Lactobacillus titer than the control group (37.5% versus 15%) by both the total number of diseases and individual conditions associated with a lower Lactobacillus titer.
Conclusion. There is a need for further investigations of the effectiveness of prevention of opportunistic vaginal infections with hygiene products containing probiotic Lactobacillus strains on larger patient groups, by typing the Lactobacilli isolated from the vaginal secretions of women.

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About the Authors

Lyubasovskaya L.A., PhD, Head of the Unit of clinical pharmacology, Department of microbiology and clinical pharmacology, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79060744246. E-mail: l_lyubasovskaya@oparina4.ru
Melkumyan A.R., PhD, Researcher in the Microbiology Laboratory, of the National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79032641257. E-mail: alinamelkumyan@yandex.ru
Dubodelov D.V., PhD, Head of the Laboratory of microbiology, Department of microbiology and clinical pharmacology, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79037724715. E-mail: d_dubodelov@oparina4.ru
Rodchenko J.V., Bacteriologist in the Laboratory of microbiology, Department of microbiology and clinical pharmacology, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79653746373. E-mail: docrodchenko@mail.ru
Kondrakhin A.P., PhD, Researcher in the Unit of clinical pharmacology, Department of microbiology and clinical pharmacology, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79099119899. E-mail: a_kondrakhin@oparina4.ru
Maykova G.B., Junior researcher in the Unit of clinical pharmacology, Department of microbiology and clinical pharmacology, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79258608727. E-mail: g_maykova@oparina4.ru
Amirkhanyan A.S., Postgraduate student, Head in the Unit for Clinical Affairs, Science and Outpatient Department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: a_amirkhanyan@oparina4.ru
Nikolaeva N.V., PhD, Dermatovenerologist of the State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency.
123098, Russia, Moscow, Gamaleya str. 15-2. Tel.: +79037293777. E-mail: nnv1310@mail.ru
Muravieva V.V., Senior researcher, PhD in the Laboratory of microbiology, Department of microbiology and clinical pharmacology, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382533. E-mail: v_muravieva@oparina4.ru
Bairamova G.R., Doctor of science, Head in the Unit for Clinical Affairs, Science and Outpatient Department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79099947700. E-mail: g_bairamova@oparina4.ru
Priputnevich T.V., Doctor of science, Head of the Department of microbiology and clinical pharmacology, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79032641257. E-mail: priput1@gmail.com

For citations: Lyubasovskaya L.A., Melkumyan A.R., Dubodelov D.V., Rodchenko Yu.V., Muravyeva V.V., Kondrakhin A.P., Maikova G.B., Amirkhanyan A.S., Nikolaeva N.V., Bairamova G.R., Priputnevich T.V. Experience with sanitary products containing the probiotic strain Lactobacillus acidophilus in reproductive-aged and postmenopausal women for the prevention of opportunistic vaginal infections. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (9): 126-31. (in Russian)
https://dx.doi.org/10.18565/aig.2018.9.126-131

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