Experience with interferon-gamma in the therapy of sexually transmitted viral infections

Rakhmatulina M.R., Bolshenko N.V.

1 State Research Center of the Russian Federation - A.I. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of Russia, Moscow; 2 Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 3 Moscow Regional Clinical Dermatovenereology Dispensary, Moscow, Russia
Objective. To investigate the efficacy and safety of Ingaron (interferon-gamma) in the combined therapy of sexually transmitted viral infections (STVIs).
Subjects and methods. The investigation included 26 patients diagnosed with anogenital herpetic infection (Subgroups 1A and 1B) and 64 patients with anogenital (venereal) warts (Subgroups 2A, 2B, 2C, and 2D). Subgroup 1A received combined therapy with acyclovir and Ingaron; Subgroup 1B took acyclovir only; Subgroup 2A had Ingaron in combination with cryodestruction; Subgroup 2B received cryodestruction; and Subgroup 2C took Ingaron in combination with destruction with Solcoderm; Subgroup 2D had destruction with Solcoderm.
Results. Recurrent anogenital herpetic infection was absent in 92.9% of the patients receiving combined therapy with acyclovir and Ingaron and in 58.3% of those on acyclovir therapy. In patients with anogenital warts, the efficiency of combined therapy (Ingaron + cryodestruction; Ingaron + Solcoderm) exceeded that of therapy with cryodestruction only or with Solcoderm: 94.1, 93.3, 58.8, and 40.0%, respectively. During therapy, there were no serious adverse events or clinically significant changes in the general clinical and biochemical blood tests.
Conclusion. The use of Ingaron in the combined therapy of viral STVIs demonstrates a high clinical efficacy and safety profile and assists in reducing the rate of recurrence.


papillomavirus infection
anogenital warts
genital herpes


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Received 19.11.2018

Accepted 07.12.2018

About the Authors

Rakhmatulina, Margarita R., MD, professor of the Department a dermatovenereology and cosmetology with a course of clinical laboratory diagnostics, State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency.
123098, Russia, Moscow, Zhivopisnaya str., 46. Tel.: +79162031003. E-mail: ra.marg@yandex.ru
Bolshenko, Natalia V., PhD, the head researcher of Federal Budget Institution of Science “Central Research Institute of Epidemiology” of The Federal Service on Customers’ Rights Protection and Human Well-being Surveillance.
111123, Russia, Moscow, Novogireevskaya str. 3a. The chief of the consultative-diagnostic department Moscow Regional Clinical Dermatovenerological Center, Moscow, Russia. 111123, Russia, Moscow, Schepkina str. 61/2, building 2. Tel.: +79164224280. E-mail: sanabol@mail.ru

For citations: Rakhmatulina M.R., Bolshenko N.V. Experience with interferon-gamma in the therapy of sexually transmitted viral infections. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (12): 149-56. (in Russian)

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