Combination therapy for papillomavirus infection

Rakhmatulina M.R.

A.I. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of Russia, Moscow 123098, Zhivopisnaya str. 46, Russia
Objective. To analyze the data available in the current literature on the epidemiology, etiology, and treatments of the clinical manifestations of papillomavirus infection. To systematize the results of investigating the clinical efficiency of using inosine pranobex (isoprinosine) in patients with different forms of papillomavirus infection.
Material and methods. Foreign and Russian articles published on the investigation topic were analyzed.
Results. The paper gives an update on the epidemiology, etiology, and treatments of the clinical manifestations of papillomavirus infection. It describes the results of investigating the efficiency of monotherapy and combination treatment for papillomavirus infection with inosine pranobex (isoprinosine).
Conclusion. The current investigations have established the high efficiency of using inosine pranobex to treat human papillomavirus infection: in combination therapy (87.5–97%) and in monotherapy (72.4–95%). There is evidence for an improvement in the regeneration processes in the genital tract mucous membrane when isoprinosine is used after destructive therapy and an increase in the rate of human papillomavirus elimination as a result of the treatment.


human papillomavirus
papillomavirus infection
antiviral therapy
inosine pranobex


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Received 08.09.2017

Accepted 22.09.2017

About the Authors

Rakhmatulina Margarita Rafikovna, MD, Professor of the Department of Dermatovenereology and Cosmetology with the Course of Clinical Laboratory Diagnostics,
A.I. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of Russia.
123098, Russia, Moscow, Zhivopisnaya str. 46. Tel.: +79162031003. E-mail:

For citations: Rakhmatulina M.R. Combination therapy for papillomavirus infection. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (12): 122-5. (in Russian)

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