Local antibacterial therapy in the combination treatment of patients with HPV-associated diseases of the cervix uteri

Kononova I.N., Kareva E.N.

1 Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg 620028, Repina str. 1, Russia; 2 N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow 117997 Ostrovitianova str. 1, Russia; 3 I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow 119991, Bolshaya Pirogovskaya str. 2-4, Russia
Objective. To investigate the clinical efficacy of Elgyna in the medical treatment of human papillomavirus (HPV)-associated cervical intraepithelial neoplasias (CIN).
Subject and methods. The results of antibacterial therapy prior to destructive treatment were comparatively analyzed in 53 patients with severe dysbiosis in HPV-associated CIN. A study group included 27 patients who took the combined drug Elgyna as one vaginal tablet twice daily (6 administrations); a comparison group of 27 patients received the combined drug Tergynan as one vaginal tablet twice daily (6 administrations). A control group comprised 20 women with the visually unchanged cervix. All the women underwent standard examinations and vaginal microbiocenosis estimation by RT-PCR assay using the Femoflor test.
Results. The use of the combined drug Elgyna during medical treatment before destruction was found to normalize molecular biological parameters at the local level and contributes to a significant reduction in the time of epithelialization and a decline in the number of recurrences.
Conclusion. HPV-associated cervical neoplasias are accompanied by the development of pronounced dysbiotic processes in the vagina with the predominant involvement of obligate anaerobes. Taking into account the properties of the combined drug Elgyna that provides a normalizing effect on the parameters of biocenosis in accelerating healing and in preventing a recurrence of the process, it is appropriate to prescribe the drug before destructive treatments.


cervical intraepithelial neoplasias
papillomavirus infection
combination treatment


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Received 08.06.2018

Accepted 22.06.2018

About the Authors

Kononova lrina Nikolaevna, MD, PhD, Chief Scientific Researcher, Research Institute of Maternal and Infant Care, Ministry of Health of Russia. 
620028, Russia, Yekaterinburg, Repina str. 1. Tel.: +73433718911. E-mail: irkonmed@mail.ru
Kareva Elena Nikolaevna, MD, PhD Professor of Academician P.V. Sergeev Department of Molecular Pharmacology and Radiobiology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Professor of Department of Pharmacology of the Faculty of General Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia. 119991, Russiа, Moscow, Bolshaya Pirogovskaya str. 2-4

For citations: Kononova I.N., Kareva E.N. Local antibacterial therapy in the combination treatment of patients with HPV-associated diseases of the cervix uteri. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (7): 103-7. (in Russian)

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