Epidemiology of human papillomavirus infection and HPV-associated female genital cancers in the Sverdlovsk region

Kononova I.N., Bashmakova N.V., Berzin S.A., Borisevich G.A., Martem’yanova V.V., Kuznetsova Yu.N., Shmakova Yu.A.

1) Ural Research Institute of Maternity and Child Care of Minzdrav of Russia, Yekaterinburg, Russia; 2) Ural State Medical University of Minzdrav of Russia, Department of Oncology and Medical Radiology, Yekaterinburg, Russia; 3) Ministry of Health of the Sverdlovsk Region, Yekaterinburg, Russia; 4) Kachkanar Central City Hospital, Kachkanar, Sverdlovsk Region, Russia
Implementation of the cancer prevention program showed the need to investigate regional epidemiological features of human papillomavirus infection and HPV-associated female genital cancers in the Sverdlovsk region.
Aim. To identify the main epidemiological patterns of the prevalence of human papillomavirus infection, HPV-associated female genital cancers in the Sverdlovsk region for the scientific validation of the criteria for the adoption of the regional Preventive Screening and Vaccination Program.
Materials and methods. This was a prospective cohort study of 2567 women. Also, a retrospective study of the oncological morbidity of the reproductive organs in the Sverdlovsk region was conducted based on official statistics from 2008 to 2018.
Results. HPV DNA was detected in 48.8% of women, of which 67.7 ± 6.5% had high-risk oncogenic HPV types. The incidence of malignant neoplasms in the Sverdlovsk region was 431.1 per 100,000 of the population and 11.7% of them were HPV-associated. During the study period, the incidence of cervical cancer increased in the region by 24.3%, with a mean annual increase of 2.2%. Among cancers of rare locations, there was a significant 36.7% increase in the incidence of vulvar cancer.
Conclusion Unfavorable epidemiologic changes in HPV-associated diseases in the Sverdlovsk region may serve as a scientific rationale for optimizing screening and adopting a regional preventive vaccination program.

Keywords

papillomavirus infection
HPV-associated cervical cancer

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Received 23.12.2019

Accepted 09.01.2020

About the Authors

Irina N. Kononova, MD, PhD, Federal State Budgetary Institution Ural Research Institute for Maternal and Child Care of Ministry of Healthcare of Russian Federation.
Тел.: +7(343)371-89-11. E-mail: irkonmed@mail.ru
620028 Russia, Еkaterinburg, Repin, 1. 
Nadezhda V. Bashmakova, MD, PhD, Chief Scientific Researcher, Professor Federal State Budgetary Institution “Ural Research Institute for Maternal and Child Care” of Ministry of Healthcare of Russian Federation, Honored Doctor of the Russian Federation, Chief obstetrician-gynecologist of the Ural Federal District.
Тел.: +7(343)371-87-68. E-mail: dr@niiomm.ru
620028 Russia, Еkaterinburg, Repin, 1. 
Berzin S.A., MD, PhD, Professor of the Department of Oncology and medical radiobiology Federal state budgetary educational institution of higher education Ural state medical University of the Ministry of health of Russia. Тел.: +7(912)2451121. E-mail: berzin43@yandex.ru
620036 Yekaterinburg, st. Soboleva, 29, p. 2.
Galina A. Borisevich, Chief Epidemiologist of the Ministry of Health of the Sverdlovsk Region. Тел.: +7(343)3120003 (доб.921), e-mail: borisevich@egov66.ru
620014 Russia, Yekaterinburg, st. Weiner, 34B,
Valeriya V. Martemyanova, Head physician State budgetary institution of health care of the Sverdlovsk region “Kachkanar central city hospital”, Kachkanar, Sverdlovsk region, Russia. Тел.:+7(34341)61532, e-mail: kcgb_glav@mail.ru
624351, Sverdlovsk Region, Kachkanar, Sverdlova St., 42/1.
Yulia N. Kuznetsova, Head of the Women’s Consultation at the Kachkanar Central City Hospital. Тел.: +7(34341)61532, e-mail: kcgb _glav@mail.ru
624351, Sverdlovsk Region, Kachkanar, Sverdlova St., 42/1.
Nadezhda A. Shmakova, obstetrician-gynecologist of the highest category, postgraduate student of FSBI Ural Research Institute of OMM of the Ministry of Health of Russia. Тел.: +7(343)371-89-11. E-mail: nadyuschka.ru@yandex.ru
620028 Russia, Еkaterinburg, Repin, 1.

For citation: Kononova I.N., Bashmakova N.V., Berzin S.A., Borisevich G.A., Martem’yanova V.V., Kuznetsova Yu.N., Shmakova Yu.A. Epidemiology of human papillomavirus infection and HPV-associated female genital cancers in the Sverdlovsk region.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 1(Suppl): 74-80.(in Russian)
https://dx.doi.org/10.18565/aig.2020.1suppl.74-80

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