Experience with ginger in the treatment of nausea and vomiting of pregnancy

DOI

https://dx.doi.org/10.18565/aig.2022.7.96-102

Khabarov S.V.
1) Medical Institute, Tula State University, Tula, Russia; 2) Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of Russia», Moscow, Russia; 3) VITROMED LLC, Moscow, Russia

Background: Nausea and vomiting of pregnancy are the most common symptoms of progressive gestation and occur in 70–80% of pregnant women. Nausea and vomiting of pregnancy are associated with certain adverse outcomes for the mother, fetus, and offspring, whereas their level has a significant negative impact on different aspects of women's quality of life, including working capacity, family relationships, - the ability to lead a usual social life and the willingness to become pregnant again.
Objective: To study the efficacy of ginger extract in nausea and vomiting of pregnancy.
Materials and methods: The observational study included 94 women at 6 to 16 weeks’ gestation with mild to moderate nausea and/or vomiting of pregnancy. The patients’ quality of life and health were assessed in a questionnaire before, during, and after the end of a treatment cycle, by determining the socioeconomic status, habits, and lifestyle from the Sickness Impact Profile questionnaire and the severity of nausea and vomiting of pregnancy from the Pregnancy-Unique Quantification of Emesis and Nausea. The efficacy of the Preginor complex for nausea and vomiting of pregnancy was evaluated at the end of the cycle of its administration and compared with the baseline values.
Results: By the end of therapy with the complex, 37.2% of patients did not complain of nausea and vomiting and they did not require further administration of Preginor. Nausea and vomiting were assigned as mild in 55.3% of pregnant women. Only 7.5% of the women who participated in the study did not report any considerable positive changes in their health when taking the complex; they continued to have moderate nausea and vomiting with a lower symptom intensity, which improved the pregnant women’s general condition and quality of life. However, the number of these patients declined 4-fold. There was a 2.2-fold decrease in the mean total index of nausea and vomiting after a treatment cycle.
Conclusion: The intake of the non-pharmacological complex Preginor substantially relieves the symptoms of nausea and vomiting and improves their quality of life. In our opinion, the use of Preginor as a dietary supplement is promising and causes its wider clinical introduction.

nausea

vomiting

pregnancy

hyperemesis gravidarum

аntiemetic agents

ginger

gingerols

Preginor

quality of life

Full text (in Russian)

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Received 08.07.2022

Accepted 14.07.2022

Sergey V. Khabarov, Dr. Med. Sci., Merited Doctor of the Russian Federation, Associate Professor, Professor at the Department of Obstetrics and Gynecology, Medical Institute, Tula State University; Professor at the Department of Clinical Laboratory Diagnostics and Pathological Anatomy, Academy of Postgraduate Education of the FMBA, +7(916)726-51-26, s.v.habarov@mail.ru, https://orcid.org/0000-0002-1736-9408, SPIN-code: 1896-1300, Scopus AuthorID: 57220038210, AuthorID: 1025053,
Researcher ID: ABB-2726-2021, 300028, Russia, Tula, Boldin str., 128.

Conflicts of interest: The author declares that there are no possible conflicts of interest.
Funding: The investigation has not been sponsored.
Ethical Approval: The investigation has been approved by the Ethics Committee of the Medical Institute, Tula State University.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Khabarov S.V. Experience with ginger in the treatment of nausea and vomiting of pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 7: 96-102 (in Russian)
https://dx.doi.org/10.18565/aig.2022.7.96-102

Experience with ginger in the treatment of nausea and vomiting of pregnancy

Khabarov S.V.

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