Optimization of combination therapy for bacterial vaginosis in reproductive-aged women
Objective. To evaluate the efficacy and tolerability of Multi-Gyn ActiGel used in the combination treatment of recurrent bacterial vaginosis (BV) in reproductive-aged women.Abashova E.I., Shalina M.A., Yarmolinskaya M.I., Misharina E.V.
Subjects and methods. Fifty reproductive-aged women with recurrent BV were randomized equally into 2 groups: 1) those who received a standard two-stage treatment regimen with clindamycin phosphate vaginal cream 2% for 7 days, followed by intravaginal application of Multi-Gyn ActiGel for 5 days; 2) those who used long-term treatment: after the standard regimen they continued to have Multi-Gyn ActiGel twice weekly for 3 months. BV was diagnosed using the clinical data, Amsel’s criteria, and microscopic and molecular techniques. The effectiveness of treatment for BV was evaluated 1 and 3 months after start of therapy.
Results. The effectiveness of therapy at 1 month after start of two-stage treatment in patients with recurrent BV in both groups was high and amounted to 88% and 84%, respectively. Following 3 months, the recurrent BV rate was significantly lower among the women receiving the long-term treatment regimen (p < 0.05) and was confirmed by clinical and laboratory data than that in patients with the standard regimen using intravaginal Multi-Gyn ActiGel.
Conclusion. Multi-Gyn ActiGel is well-tolerated, convenient, and easy-to-use, has no side effects, thus shows high compliance, including that during its long-term use. The long-term use of intravaginal Multi-Gyn ActiGel in the two-stage treatment of bacterial vaginosis significantly (p < 0.01) increases the number of lactobacilli in the vaginal biotope, reduces vaginal pH values, and restores normal microflora, which allows a relapse of the disease to be prevented in 80% of patients with bacterial vaginosis.
Keywords
bacterial vaginosis
Multi-Gyn ActiGel
Amsel’s criteria
key cells
Femoflor test
clindamycin
Atopobium vaginae
Supplementary Materials
References
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Received 08.09.2017
Accepted 22.09.2017
About the Authors
Abashova Elena Ivanovna, Candidate of Medical Science, Senior Researcher, Department of Endocrinology Reproduction, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction. 199034, Russia, St. Petersburg, Mendeleevskaya line, 3. Tel.: +78123289820, +79219459090. E-mail: abashova@yandex.ruShalina Maria Aleksandrovna, MD, doctor obstetrician-gynecologist of the department of gynecological endocrinology, D.O. Ott Research Institute of Obstetrics,
Gynecology and Reproduction. 199034, Russia, St. Petersburg, Mendeleevskaya line, 3. Tel.: +78123289820, +79219348777. E-mail: amarus@inbox.ru
Yarmolinskaya Maria Igorevna, Professor of the Russian Academy of Sciences, Head of the Department of Endocrinology of Reproduction, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction. 199034, Russia, St. Petersburg, Mendeleevskaya line, 3. Tel.: +78123289820, +79219166903. E-mail: m.yarmolinskaya@gmail.com
Misharina Elena Vladimirovna, Candidate of Medical Science, senior researcher of the Department of Endocrinology Reproduction, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction. 199034, Russia, St. Petersburg, Mendeleevskaya line, 3. Tel.: +78123289820, +79219558524. E-mail: mishellena@gmail.com
For citations: Abashova E.I., Shalina M.A., Yarmolinskaya M.I., Misharina E.V. Optimization of combination therapy for bacterial vaginosis in reproductive-aged women. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (11): 134-40. (in Russian)
https://dx.doi.org/10.18565/aig.2017.11.134-140
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