Obesity, metabolic syndrome, and thrombophilia

Khromylev A.V., Makatsaria A.D.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow 119048, Trubetskaya str. 8, bld. 2, Russia
Objective. To comprehensively analyze the data available in the current literature on a pathogenetic relationship between obesity and thrombophilia in the development of obstetric and thrombotic events in female patients with metabolic syndrome (MS).
Material and methods. The review included the data of foreign and Russian articles published in the past 10 years and found in PubMed and e-Library on this topic.
Results. The paper clearly shows possible mechanisms and a pathogenetic relationship between endocrine, proinflammatory, and prothrombotic statuses observed in patients with MS in the development of obstetric and thrombotic events.
Conclusion. Despite a significant number of investigations of the risk factors and pathogenetic mechanisms for the development of thromboembolic events in MS patients, the problem of identifying the causes and ways of correcting the abnormalities has not been fully resolved and requires further study. Moreover, the annually increasing percent of persons with obesity and metabolic syndrome among reproductive-aged women poses new challenges of optimizing their preparation for pregnancy and preventing thrombohemorrhagic complications during pregnancy, delivery, and the postpartum period.

Keywords

metabolic syndrome
obesity
atherosclerosis
thrombotic events
thrombosis
thrombophilia
antithrombotic therapy

Supplementary Materials

  1. Picture. The pathogenic mechanisms of atherothrombotic risk in obesity, metabolic syndrome, and thrombophilia [39]. Notice: antiphospholipid antibodies (APLAs), plasminogen activator inhibitor 1 (PAI-1), free fatty acids (FFAs).

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Received 16.01.2017

Accepted 17.02.2017

About the Authors

Khromylev Aleksei Viktorovich, graduate student of the Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University.
119048, Russia, Moscow, Trubetskaya str. 8, bld. 2. E-mail: khromilev@mail.ru
Makatsariya Aleksandr Davidovich, MD, corresponding member of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medical and Preventive, I.M. Sechenov First Moscow State Medical University. 119048, Russia, Moscow, Trubetskaya str. 8, bld. 2. Tel.: +74957885840.
E-mail: gemostasis@mail.ru

For citations: Khromylev A.V., Makatsaria A.D. Obesity, metabolic syndrome, and thrombophilia. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (10): 27-33. (in Russian)
https://dx.doi.org/10.18565/aig.2017.10.27-33

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