Assessment of the informative value of a regional cervical screening program

Gatagazheva Z.M., Uzdenova Z.Kh., Zelenova O.V.

1) Faculty of Medicine, Ingush State University, Nazran, Russia; 2) Faculty of Medicine, Kh.M. Berbekov Kabardino-Balkar State University, Nalchik, Russia; 3) Central Research Institute of Health Organization and Informatization, Ministry of Health of the Russian Federation, Moscow, Russia
To assess the results of using a careHPV test kit as a quick screening test in the organized cervical cancer (CC) screening program in the Republic of Ingushetia. Human papillomavirus (HPV) testing was carried out in 1000 women aged 30 to 60 years to identify 14 high-risk HPV types, by using the hybrid capture assay. High-risk HPV was detected in 107 (10.7%) women. All the women (n = 107) were referred to visual inspection with acetic acid; and 81 (75.7%) women of them underwent a cytological examination of cervical smears for suspected dysplasia. Fifteen (1.5%) women with cytologically verified CIN II-III were sent to the Republican Oncology Dispensary for cervical excision with histological examination of biopsy specimens.Taking into account that HPV infection is a major etiological factor for the pathogenesis of CC, in order to reduce its morbidity and mortality, it is recommended that HPV testing should be introduced into the algorithm of the organizational form of early CC diagnosis among the republic’s female population aged 30 to 60 years.

Keywords

human papillomavirus
cervical cancer
screening
Republic of Ingushetia

References

  1. Bruni L., Barrionuevo-Rosas L., Albero G. et al. ICO Information Centre on HPV and Cancer (HPV ICO Information Centre). Human Papillomavipus and Related Diseases in the World Summary Report. 2016.
  2. Global Guidance For Cervical Cancer Prevention and Control October FIGO 2009.
  3. Society of Gynecologic Oncologi (SGO) and the American Society for Colposcopy and Cervical Pathology (ASCCR): Interim clinical for primary guidance hrHPV testing 2015.
  4. Comprehensive cervical cancer control: a guide to essential practice. WHO 2 ed. 2014; 393.
  5. Khunamornpong S., Setakorn J., Sukpan K. ,Suprasert P., Srisomboon J. Genotyping for Human Papillomavirus (HPV) 16/18/52/58 Has a Higher Performance than HPV 16/18 Genotyping. 2016 Jun 23; 11 (6): е015884. Doi: 10.1371/ journail.pone.01587184.
  6. Артымук Н.В., Марочко К.В. Эффективность выявления вируса папилломы человека при помощи устройства для самостоятельного забора вагинального отделяемого. Акушерство и гинекология. 2016; 3: 85-91.[Artymuk N.V., Marochko K.V. Efficiency of detecting human papillomavirus using a device for self-collection of vaginal discharge. Akusherstvo i ginekologiya/ Obstetrics and gynecology. 2016; 3: 85-91. (In Russian)]
  7. Белокриницкая Т.Е., Туранова О.В., Фролова Н.И. Сравнительная оценка прогностической ценности самостоятельного и врачебного забора материала для ВПЧ-теста. Гинекология. 2018; 20(26): 51-54.[Belokrinitskaya T.E., Turanova O.V., Frolova N.I. Comparative assessment of the prognostic value of independent and medical sampling of materialfor HPV-test. Gynecology. 2018; 20(26): 51-54. (In Russian)]
  8. Гатагажева З.М., Никитина В.П., Неродо Г.А., и др. Оптимизация выявления и лечения заболеваний шейки матки, выявленных на «Открытом приеме» в Республике Ингушетия. Современные проблемы науки и образования. 2016; 4: 8. Available at: http://www.science-education.ru/ru/article/view [Gatagazheva Z.M., Nikitina V.P., Nerodo G.A., et al. Optimization of the detection and treatment of cervical diseases detected at the Open Reception in the Republic of Ingushetia. Modern problems of science and education .2016; 4: 8: http://www.science-education.ru/ru/article/view. (In Russian)]
  9. Молочков В.А., Киселев В.И., Рудых И.В., Щербо С.Н. Папилломавирусная инфекция: клиника, диагностика, лечение: пособие для врачей. М.: МОНИКИ; 2014. [Molochkov V.A., Kiselev V.I., Rudykh I.V., Scherbo S.N. Human papillomavirus infection: clinic, diagnosis, treatment: a manual for doctors. M.: MONIKI; 2014. (In Russian)]
  10. Киселев В.И., Муйжнек Е.Л. Молекулярные механизмы развития дисплазии шейки матки: новые знания – новые возможности. М., 2012. [Kiselev V.I., Muizhnek E.L. Molecular mechanisms of development of cervical dysplasia: new knowledge – new opportunities. M., 2012. (In Russian)]
  11. Прилепская В.Н., ред. Инфекции, передающиеся половым путем. Клинические лекции. М.: ГЭОТАР-Медиа; 2014. 160 с. [Prilepskaya V.N. ed. Sexually transmitted infections. Clinical lectures. M.: GEOTAR-Media;2014. 160 p. (In Russian)]
  12. Kreimer A.R. Clinical lectures. HPV and Extra-Cervical Cancers. U.S. National Cancer Institute. Epidemiology, Prevention, and Control of Site-Specific Tumors; 2009.
  13. Collins S., Mazloomzadeh S., Winter H., et al. High incidence of cervical human papillomavirus infection in women during their first sexual relationship. BJOG. 2012; 109(1): 96-8.
  14. Bosch F.X., Lorincz A., Muñoz N., et al. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2012; 55(4): 244-65.
  15. Munoz N., Bosch F.X., Shah K.V. (eds). The epidemiology of human papillomavirus and cervical cancer. Lyon: IARC; 2012.

Reseived 18.02.2109

Accepted 22.02.2019

About the Authors

Gatagazheva Zareta Magomedovna, PhD, Associate Professor, Head of the Department of Obstetrics and Gynecology, Ingush State University, Nazran, Russia.
Аddress: 386001 RI, Magaz, I. B. Zjazikova avenue, 7; Phone:+7 (8732) 223854, е-mail:ing_gu@mail.ru
Uzdenova Zukhra Khadzhimuratovna, MD, Professor of the Department of Pediatric Diseases, Faculty of Medicine of Obstetrics and Gynecology, FSBEI HE "Kabardino-Balkarian State University. H.M. Berbekova ", Nalchik, Russia
Аddress: 360004, Kabardino-Balkar, Nalchik, of Chernyshevsky St., 173 (8662) 40-85-33, 9280847779, elifiya@bk.ru
Zelenova Olga Vasilievna, MD, Professor of the Federal State Budgetary Institution “Central Research Institute for the Organization and Informatization of Health Care”Аddress: 127254, 11 Dobrolyubova street, Moscow, Russia.

For citations: Gatagazheva Z.M., Uzdenova Z.Kh., Zelenova O.V. Assessment of the informative value of a regional cervical screening program. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (7): 98-102 (in Russian).
http://dx.doi.org/10.18565/aig.2019.7.98-102

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.