Evaluation of the efficiency and safety of topical application of the bacteriophage-containing gels Fagogin and Fagoderm for the prevention of wound complications in puerperas
Objective: to evaluate the efficacy and safety of complex bacteriophage-containing agents on a gel basis (the gels Fagogin and Fagoderm) for the prevention of wound complications in the postpartum period.Priputnevich T.V., Lyubasovskaya L.A., Ignatyeva A.A., Karapetyan T.E., Chubarov V.V., Zurabov A.Yu., Popova V.M., Zhilenkov E.L.
Material and methods. Fagogin and Fagoderm contain a set of 40 bacteriophages that suppress the growth of opportunistic pathogenic microorganisms (OPMs) found on the vaginal mucosa and skin. The investigation enrolled 141 patients, including 66 (Fagogin users) after spontaneous labor and 75 (Fagoderm users) after cesarean section; the sutures were treated with the prophylactic agent Fagogin in 18 of them and with the prophylactic agent Fagoderm in 25; 98 patients formed a control group (suture treatment with potassium permanganate).
Results. The efficacy of Fagogin and Fagoderm is confirmed by the absence of cases of wound infections during wound treatment with the test agents. There were no statistically significant differences in the assessment of subjective sensations in the women of the Fagogin and Fagoderm groups and in those of the control group. Fagogin and Fagoderm were tested for microbiological efficacy on 161 OPM strains with different antibiotic susceptibility, which were isolated from vaginal discharge in reproductive-aged women. The prophylactic agents, including those against antibiotic-resistant microorganisms, were shown to have a high antimicrobial activity.
Conclusion. The findings confirm the efficacy and safety of Fagogin and Fagoderm for the prevention of infectious complications in puerperas.
Keywords
bacteriophages
opportunistic infections
postpartum complications
prevention
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Reseived 10.12.2018
Accepted 22.02.2019
About the Authors
Priputnevich Tatiana V, Head of the Department of microbiology, clinical pharmacology and epidemiology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health, Russian Federation, PhD, Doctor of Science.Address: 4, Oparin st., Moscow, 117997, Russia. Phone: 8 (910) 414-56-16, e-mail: priput1@gmail.com.
Lyubasovskaya Lyudmila A, Head of the Unit of clinical pharmacology, Department of microbiology, clinical pharmacology and epidemiology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health, Russian Federation, PhD.
Address: 4, Oparin st., Moscow, 117997, Russia. Phone: 8 (906) 074-42-46, e-mail: labmik@yandex.ru.
Ignateva Alla A, Head of II Department of Obstetrics Phisiology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health, Russian Federation, PhD.
Address: 4, Oparin st., Moscow, 117997, Russia. Phone: 8(916) 928-96-38, e-mail: Ignateva-alla@mail.ru.
Karapetyan Tamara E., High scientific researches of Obstetric department, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health, Russian Federation, PhD.
Address: 4, Oparin st., Moscow, 117997, Russia. Phone: 8(916) 928-96-38, e-mail: tomamed02@mail.ru.
Chubarov Valeriy V., Head of Department of epidemiology, Department of microbiology, clinical pharmacology and epidemiology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health, Russian Federation, PhD.
Address: 4, Oparin st., Moscow, 117997, Russia. Phone: 88 (929) 997-91-21, e-mail: v_chubarov@oparina4.ru.
Zurabov Alexander Y, CEO of Research and Production Centre “MicroWorld” Ltd., Moscow, Russian Federation
Address: 107031, Moscow, Nizhnij Kisel`nyj per, 5/23, str.1 tel., 8(495)625-37-67, e-mail: azurabov@micro-world.ru
Popova Valentina M, Deputy of CEO of Research and Production Centre “MicroWorld” Ltd., Moscow, Russian Federation
Address: 107031, Moscow, Nizhnij Kisel`nyj per, 5/23, str.1 tel., 8(495)625-37-67, e-mail: popovavm9@yandex.ru
Zhilenkov Evgeny L, Deputy of CEO of Research and Production Centre “MicroWorld” Ltd., Moscow, Russian Federation
Address: 107031, Moscow, Nizhnij Kisel`nyj per, 5/23, str.1 tel., 8(495)625-37-67, e-mail: zhilenkovevgeny@gmail.com
For citation: Priputnevich T.V., Lyubasovskaya L.A., Ignatyeva A.A., Karapetyan T.E., Chubarov V.V., Zurabov A.Yu., Popova V.M., Zhilenkov E.L.. Evaluation of the efficiency and safety of topical application of the bacteriophage-containing gels fagogin and fagoderm for the prevention of wound complications in puerperas. Akusherstvo i Ginekologiya/Obstetrics and Gynecology.2019; (6): (in Russian)
https://dx.doi.org/10.18565/aig.2019.6.126-131
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