New possibilities of therapy bacterial vaginosis: experience an antibiotic used concurrently with a prebiotic in bacterial vaginosis

DOI

https://dx.doi.org/10.18565/aig.2020.6.105-114

Manukhin I.B., Balan V.E., Dobrokhotova Yu.E., Krutova V.A., Kutueva F.R., Sakhautdinova I.V., Tapilskaya N.I., Fedulova N.M., Chernyshova L.V.
1) A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; 2) N.I. Pirogov Russian National Research Medical University, Moscow, Russia; 3) Kuban State Medical University, Krasnodar, Russia; 4) Women's Health Clinic Twenty-Two, Saint Petersburg, Russia; 5) Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia; 6) Bashkir State Medical University, Ufa, Russia; 7) D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Saint Petersburg, Russia; 8) OOO “Aurora Medi”, Saint Petersburg, Russia; 9) ZAO “Nasledniki” (Heirs), Moscow, Russia

Objective. To evaluate the efficiency and safety of therapy for bacterial vaginosis (BV) with Lactogynal vaginal capsules and clindamycin vaginal cream 2%.
Subjects and methods. Group 1 received clindamycin and Lactogynal for 7 days, then only Lactogynal for 7 days; Group 2 used clindamycin and Lactogynal for 7 days; Group 3 had clindamycin for 7 days, then Lactogynal for 7 days. After therapy, the patients were followed up for 15–24 days.
Results. At 2 weeks after therapy, the clinical cure rates were 88.9% in Group 1, 86.4% in Group 2, and 87.0% in Group 3. The laboratory cure rates according to the Amsel criteria were 95.6, 93.2, and 93.5% in Groups 1, 2, and 3, respectively; those according to the Nugent criteria were 95.6, 90.9, and 93.5% in Groups 1, 2, 3. The PCR cure rates were 77.8, 61.4, and 69.6% in Groups 1, 2, and 3, respectively. The global assessment of clinical and laboratory efficiencies revealed that the total therapeutic cure rates were 66.7% in Group 1, 59.1% in Group 2, and 63.0% in Group 3. The therapy was proven to be no less effective in the study group (Group 1) than in the control group (Group 3).
Conclusion. The trial showed that the regimen involving Lactogynal used concurrently with the antibiotic and that of sequential use of the former were comparably effective. The concurrent use of Lactogynal with antibacterial therapy to restore the normal vaginal microflora in the therapy of bacterial vaginosis can increase adherence to treatment, and, therefore, achieve its general effect.

bacterial vaginosis

Lactogynal

vaginal discharge

Full text (in Russian)

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Received 09.06.2020

Accepted 18.06.2020

Igor B. Manukhin, MD, Professor, Head of the Department of obstetrics and gynecology, Therapeutical Faculty A.I. Evdokimov MGMSU. Tel.: +7(499)178-28-31.
E-mail: katemanu@mail.ru. 20/1 Delegatskaya str., Moscow, 127473, Russia.
Vera E. Balan, MD, Professor, Head of the Polyclinic Department, Moscow regional Research Institute of Obstetrics and Gynecology. Tel.: +7(495)624-50-66.
E-mail: balanmed@gmail.com. 22A Pokrovka str., Moscow, 101000, Russia.
Yulia E. Dobrokhotova, N.I. Pirogov RNRMU HPE SEI, Therapeutical Faculty, Obstetrics and Gynecology Department. Tel: +7(495)722-63-99. E-mail: pr.dobrohotova@mail.ru.
1/9 Ostrovitianov str., Moscow, 117997, Russia.
Viktoriya A. Krutova, MD, Professor of the Department of obstetrics, gynecology and Perinatology, Kuban State Medical University of the Ministry of Health of the Russian Federation. Tel: +7(861)275-60-70. Email: vik_krutova@yandex.ru. 4 Sedina str., Krasnodar, 350072, Russia.
Flora R. Kutueva, PhD, Honored Doctor of the Russian Federation, assistant of the Department of obstetrics and gynecology, Saint Petersburg State Pediatric Medical University Ministry of Health of the Russian Federation. Tel: +7(812)296-31-08. E-mail: flora-kutueva@mail.ru. 2 Litovskaya str., Saint Petersburg, 194100, Russia.
Indira V. Sakhautdinova, MD, Professor, Head of the Department of obstetrics and gynecology No. 1 FGBOU HE “Bashkir State Medical University” of the Ministry of Health of the Russian Federation. Tel: +7(347)272-41-73. E-mail: indira2127@yandex.ru. 23 Tukaeva str., Ufa, 450002, Republic of Bashkortostan.
Natalia I. Tapilskaya, MD, Professor of the Department of obstetrics and gynecology with the course of gynecology for children, Saint Petersburg State Pediatric Medical University Ministry of Health of the Russian Federation. Tel: +7(812)328-98-22. E-mail: tapnatalia@yandex.ru. 2 Litovskaya str., Saint Petersburg, 194100, Rusia.
Natalia M. Fedulova, obstetrician-gynecologist at Aurora Medi LLC., Tel: +7(812)333-00-22. E-mail: fedulovaru1@rambler.ru.
5-3 Kievskaya str., Saint Petersburg, 196084, Russia.
Lyudmila V. Chernyshova, obstetrician-gynecologist, Deputy chief physician of JSC “Inheritors”. Tel: +7(495)730-17-00. E-mail: 7251336@mail.ru.
7 Michurinsky prospekt, Moscow, 119192, Russia.

For reference: Manukhin I.B., Balan V.E., Dobrokhotova Yu.E., Krutova V.A., Kutueva F.R., Sakhautdinova I.V., Tapilskaya N.I., Fedulova N.M., Chernyshova L.V. New possibilities of therapy bacterial vaginosis: experience an antibiotic used concurrently with a prebiotic in bacterial vaginosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 6: 105-114 (in Russian).
https://dx.doi.org/10.18565/aig.2020.6.105-114

New possibilities of therapy bacterial vaginosis: experience an antibiotic used concurrently with a prebiotic in bacterial vaginosis

Manukhin I.B., Balan V.E., Dobrokhotova Yu.E., Krutova V.A., Kutueva F.R., Sakhautdinova I.V., Tapilskaya N.I., Fedulova N.M., Chernyshova L.V.

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