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Obstetrics and Gynegology2022№10
New technologies in solving the...

New technologies in solving the problems of preeclampsia

DOI
https://dx.doi.org/10.18565/aig.2022.10.5-13

Nikitina N.A., Sidorova I.S., Ageev M.B., Timofeev S.A., Kiryanova M.A., Morozova E.A.

Obstetrics and Gynecology Department No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia
This review deals with the current state of the problem of preeclampsia in obstetrics. It is emphasized that hypertensive disorders and preeclampsia still retain their positions among the leading causes of maternal death in Russia in the presence of a progressive increase in the incidence of severe preeclampsia. The high percentage of preventable and potential preventable cases of maternal death due to preeclampsia (72.5% in 2020) suggests that there is a need for further improvement of the management strategy for these patients, as well as a deeper study of the pathophysiological mechanisms responsible for the development of this pregnancy complication. The paper emphasizes that the concept of failure of cytotrophoblast invasion as a cause of preeclampsia is currently in doubt. Taking into account the modern principles of personalized medicine, there is a need for innovative large-scale, high-throughput, unbiased researches. These requirements are met by the latest methods in systems biology, in particular, the so-called omics technologies (genomics, epigenetics, transcriptomics, proteomics, and metabolomics). The paper presents studies published in the largest databases on the use of omics technologies in the study of preeclampsia.
Conclusion: A comprehensive study of the structure of a genome, as well as many ways of implementing genetic information (a systematic multi-omic design) will be able to gain a complete idea of the physiological and pathological processes, including preeclampsia.

Keywords

maternal mortality
hypertensive disorders
pregnancy
preeclampsia
transcriptomics
proteomics
transcriptome
proteome
microRNA
placental liquid biopsy
Full text (in Russian)

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Received 14.06.2022

Accepted 20.07.2022

About the Authors

Natalya A. Nikitina, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No. 1, I.M. Sechenov First Moscow State Medical University,
Institute of Clinical Medicine named after N.V. Sklifosovsky, +7(916)940-39-34, natnikitina@list.ru, https://orcid.org/0000-0001-8659-9963,
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2.
Iraida S. Sidorova, Academician of the RAS, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No. 1, I.M. Sechenov First Moscow State Medical University, Institute of Clinical Medicine named after N.V. Sklifosovsky, +7(910)438-90-87, sidorovais@yandex.ru, https://orcid.org/0000-0003-2209-8662,
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2.
Mikhail B. Ageev, PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 1, I.M. Sechenov First Moscow State Medical University,
Institute of Clinical Medicine named after N.V. Sklifosovsky, +7(916)510-90-27, mikhaageev@yandex.ru, https://orcid.org/0000-0002-6603-804X,
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2.
Sergej A. Timofeev, Teaching Assistant at the Department of Obstetrics and Gynecology No. 1, I.M. Sechenov First Moscow State Medical University,
Institute of Clinical Medicine named after N.V. Sklifosovsky, +7(916)681-31-19, satimofeev30@gmail.com, https://orcid.org/0000-0001-7380-9255,
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2.
Marina A. Kiryanova, graduate student at the Department of Obstetrics and Gynecology No. 1, I.M. Sechenov First Moscow State Medical University,
Institute of Clinical Medicine named after N.V. Sklifosovsky, +7(918)334-37-74, kiryanova.marina8@mail.ru, https://orcid.org/0000-0001-6950-5283,
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2.
Ekaterina A. Morozova, graduate student at the Department of Obstetrics and Gynecology No. 1, I.M. Sechenov First Moscow State Medical University,
Institute of Clinical Medicine named after N.V. Sklifosovsky, +7(916)123-23-30, drstrelnikova@mail.ru, https://orcid.org/0000-0002-1670-9044,
119991, Russia, Moscow, Trubetskaya str. 8, bld. 2.
Corresponding author: Marina A. Kiryanova, kiryanova.marina8@mail.ru

Authors' contributions: Sidorova I.S., Nikitina N.A. – concept and design of the investigation, editing; Timofeev S.A., Morozova E.A. – material collection and processing; Nikitina N.A., Ageev M.B., Kiryanova M.A. – writing the text.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has been conducted without additional funding.
For citation: Nikitina N.A., Sidorova I.S., Ageev M.B., Timofeev S.A., Kiryanova M.A.,
Morozova E.A. New technologies in solving the problems of preeclampsia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 10: 5-13 (in Russian)
https://dx.doi.org/10.18565/aig.2022.10.5-13

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