New advances in understanding the molecular mechanisms of human embryo implantation in in vitro fertilization programs
The data available in the modern scientific literature on the role of the uterine and embryonic factors in failed euploid embryo implantation were systematically analyzed. The keywords “microRNA”, “small non-coding RNA”, “embryo implantation”, “implantation failure”, “implantation window”, “infertility treatment”, “thin endometrium”, “endometrial receptivity”, “molecular mechanisms”, and “gene expression” were used to search for literature sources in the Russian and foreign databases eLibrary, Medline/PubMed, and Embase. Differential expression of certain blastocyst microRNAs is shown to be associated with implantation failure. The paper describes the molecules involved in the transmission of maternal signals that are activated in the blastocyst trophectoderm. It reflects the mechanism of molecular regulation in endometrial receptivity and that of formation of a thin endometrium and genes identified in the networks that may play a certain role in the development of the thin endometrium.Charaeva A.V., Makarova N.P., Drapkina Yu.S., Kalinina E.A.
Conclusion: The current evidence supports the promise of studying the molecular mechanisms of embryo implantation. Further investigations are needed to search for new biomarkers to select embryos with their good implantation potential, to assess endometrial receptivity for improving the outcomes of assisted reproductive technology programs, to reduce reproductive losses, and to give birth to healthy babies.
Authors’ contributions: Charaeva A.V., Makarova N.P. – literature data collection and analysis; Charaeva A.V., Drapkina Yu.S. – starting material processing, writing the article; Makarova N.P., Kalinina E.A. – editing the manuscript of the article.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation was supported by State Assignment No. 121040600410-7 “Solving the problem of infertility under the current conditions, by creating a clinical diagnostic model of infertile marriage and using innovative technologies in assisted reproduction programs” of the Ministry of Health of the Russian Federation.
For citation: Charaeva A.V., Makarova N.P., Drapkina Yu.S., Kalinina E.A.
New advances in understanding the molecular mechanisms of human embryo implantation in in vitro fertilization programs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (3): 21-28 (in Russian)
https://dx.doi.org/10.18565/aig.2022.281
Keywords
assisted reproductive technologies
infertility
implantation
microRNA
uterine factor
embryonic factor
female infertility
preimplantation genetic testing
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Received 25.11.2022
Accepted 02.12.2022
About the Authors
Anna V. Charaeva, Сlinical resident, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(906)352-07-16, ashcherina@yandex.ru, https://orcid.org/0000-0002-2356-586X, 117997, Russia, Moscow, Academician Oparin str., 4.Natalya P. Makarova, Dr. Bio. Sci., Leading Researcher, B.V. Leonov Department of Assisted Technologies for the Treatment of Infertility, Academician V.I. Kulakov
National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(926)409-74-32, np_makarova@oparina4.ru,
117997, Russia, Moscow, Academician Oparin str., 4.
Yulia S. Drapkina, PhD, Researcher, B.V. Leonov Department of Assisted Technologies for the Treatment of Infertility, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(916)950-07-45, julia.drapkina@gmail.com,
117997, Russia, Moscow, Academician Oparin str., 4.
Elena A. Kalinina, Dr. Med. Sci., Professor, Head of the B.V. Leonov Department of Assisted Technologies for the Treatment of Infertility, Academician V.I. Kulakov
National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(495)438-07-88, e_kalinina@oparina4.ru,
117997, Russia, Moscow, Academician Oparin str., 4.
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