Early endometrial cancer in patients with congenital malformation of the genital organs
Dvoinishnikova A.O., Shebzukhova Z.R., Pronin S.M., Khabas G.N.
Relevance: Double uterus in combination with early endometrial cancer is a very rare pathology which should be treated with extirpation of the uterus with appendages. However, it is possible to perform organ sparing hormonal treatment for reproductive-aged women who want to preserve fertility resulting in pregnancy and childbirth.
Case report: This article presents a clinical case of a patient with the double uterus in combination with early endometrial cancer who underwent a course of organ sparing hormonal therapy in order to achieve conception, become pregnant and give birth. A 28-year-old patient presented to the V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Moscow for a consultation and pregnancy planning. The comprehensive examination of the patient led to the diagnosis of highly differentiated stage Ia endometrial cancer of the right uterus and atypical hyperplasia of the endometrium of the left uterus. The patient refused surgical treatment; therefore, a course of organ sparing hormonal therapy was prescribed, which resulted in pregnancy and the birth of a healthy full-term girl.
Conclusion: Organ sparing hormonal therapy in reproductive-aged women with confirmed diagnosis of early endometrial cancer, as well as with malformation of the genital organs, makes it possible for women to preserve fertility, achieve pregnancy and reduce the risk of recurrence of the disease after childbirth and breastfeeding.
Authors' contributions: Dvoinishnikova A.O., Shebzukhova Z.R., Pronin S.M., Khabas G.N. – developing the concept and design of the study, collecting and processing the material; Dvoinishnikova A.O. – writing the text; Pronin S.M., Khabas G.N. – editing the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Patient Consent for Publication: The patient provided informed consent for the publication of their data and associated images.
For citation: Dvoinishnikova A.O., Shebzukhova Z.R., Pronin S.M., Khabas G.N. Early endometrial cancer in patients with congenital malformation of the genital organs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (5): 172-176 (in Russian)
https://dx.doi.org/10.18565/aig.2024.82
Keywords
early endometrial cancer
congenital malformation of the uterus
organ sparing treatment
pregnancy
childbirth
References
- Богданова Е.А. Гинекология детей и подростков. М.: МИА; 2000. 332 с. [Bogdanova E.A. Gynecology of children and adolescents. Moscow: MIA; 2000. 332 p. (in Russian)].
- Богданова Е.А. Практическая гинекология молодых. М.: Медицинская книга; 2018. 268 с. [Bogdanova E.A. Practical gynecology of the young. Moscow: Meditsinskaya kniga; 2018. 268 p. (in Russian)].
- Сwiertnia A., Borzyszkowska D., Golara A., Tuczynska N., Kozlowski M., Kwiatkowski S. et al. The impact of uterus didelphys on fertility and pregnancy. Int. J. Environ. Res. Public Health. 2022; 19(17): 10571. https://dx.doi.org/10.3390/ijerph191710571.
- Jorgensen C., Lusiak M. Didelphys uterus in pregnancy, an uncommon Mullerian duct anomaly: a case report. Clin. Pract. Cases Emerg. Med. 2021; 5(4): 447-9. https://dx.doi.org/10.5811/cpcem.2021.7.53212.
- Каприн A.Д., Старинский В.В., Шахзадова О.А., ред. Состояние онкологической помощи населению России в 2022 году. М.: МНИОИ им. П.А. Герцена − филиал ФГБУ «НМИЦ радиологии» Минздрава России; 2022. 239 с. [Kaprin A.D., Starinsky V.V., Shakhzadova O.A., eds. The state of oncological care for the population of Russia in 2022. Moscow: P.A. Herzen Moscow Research Institute of Radiology − branch of the Federal State Budgetary Institution "National Medical Research Center of Radiology" of the Ministry of Health of Russia; 2022. 239 p. (in Russian)].
- Kondi-Pafiti A., Spanidou-Carvouni H., Dimopoulou C., Kontogianni C.I. Endometrioid adenocarcinoma arising in uteri with incomplete fusion of Mullerian ducts. Report of three cases. Eur. J. Gynaecol. Oncol. 2003; 24(1): 83-4.
- Iavazzo C., Kokka F., Sahdev A., Singh N., Reynolds K. Uterine carcinosarcoma in a patient with didelphys uterus. Case Rep. Obstet. Gynecol. 2013; 2013: 401962. https://dx.doi.org/10.1155/2013/401962.
- Gao J., Zhang J., Tian W., Teng F., Zhang H., Zhang X. et al. Endometrial cancer with congenital uterine anomalies: 3 case reports and a literature review. Cancer Biol. Ther. 2017; 18(3): 123-31. https://dx.doi.org/10.1080/15384047.2017.1281495.
- Vázquez Vicente D., Di Fiore H.A., Garcia-Foncillas J., Plaza Arranz J. Endometrial adenocarcinoma in one horn of a didelphic uterus with vaginal duplication. BMJ Case Rep. 2014; 2014: bcr2013203280. https://dx.doi.org/10.1136/bcr-2013-203280.
- Colombo N., Preti E., Landoni F., Carinelli S., Colombo A., Marini C. et al.; ESMO Guidelines Working Group. Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2013; 24 Suppl 6: vi33-8. https://dx.doi.org/10.1093/annonc/mdt353.
- Новикова Е.Г., Чулкова О.В., Пронин С.М. Предрак и начальный рак эндометрия у женщин репродуктивного возраста. М.: МИА; 2005. 136 c. [Novikova E.G., Chulkova O.V., Pronin S.M. Precancer and initial endometrial cancer in women of reproductive age. Moscow: MIA; 2005. 136 p. (in Russian)].
- Назаренко Т.А. Стимуляция функции яичников. М.: МЕДпресс-информ; 2023. 268 с. [Nazarenko T.A. Stimulation of ovarian function. Moscow: MEDpress-inform; 2023. 268 p. (in Russian)].
Received 08.04.2024
Accepted 13.05.2024
About the Authors
Arina O. Dvoynishnikova, Clinical Resident at the Department of Obstetrics and Gynecology, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, +7(996)529-40-43, arina.dvoynishnikova@mail.ruZalina R. Shebzukhova, Oncologist, Obstetrician-Gynecologist, post-graduate at the Department of Innovative Oncology and Gynecology, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4,
+7(495)438-85-40, shbzkhv@gmail.com
Stanislav M. Pronin, PhD, Oncologist, Obstetrician-Gynecologist, Senior Researcher at the Department of Innovative Oncology and Gynecology, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4,
+7(495)438-85-40, psm_doc@mail.ru
Grigory N. Khabas, PhD, Head of the Department of Combined and Complex Methods of Treatment of Gynecological Diseases, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4, +7(495)438-09-88,
g_khabas@oparina4.ru
Similar Articles
