Molecular genetic deviations and obstetric pathology
The paper reviews international researches in the role of various gene networks in the development of obstetric pathology. It considers not only the most studied hemostatic system and folate metabolism genes, but also renin-angiotensin-aldosterone system, detoxification system, and immune response ones and genes that regulate the function of the endothelium. In addition, an update on genome-wide studies investigating a genetic predisposition to pregnancy complications is analyzed.Kovalev V.V., Kudryavtseva E.V.
Keywords
major obstetric syndromes
genetic polymorphism
clinical exome sequencing
preterm birth
preeclampsia
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Received 04.03.2019
Accepted 19.04.2019
About the Authors
Vladislav V. Kovalel, MD, prof., USMU, Department of Obstetrics and Gynecology of faculty of postgraduate education. Phone: +7(919)360-0670.E-mail: vvkovalev55@gmail.com7 620109 Russia, Ekaterinburg, Repina str., 3.
Elena V. Kudryavtseva, PhD., assotiated professor, USMU, Department of Obstetrics and Gynecology of faculty of postgraduate education. Phone: +7(922)616-4012.
E-mail: elenavladpopova@yandex.ru; https://orcid.org/0000-0003-2797-19267 620109 Russia, Ekaterinburg, Repina str., 3.
For citation: Kovalev V.V., Kudryavtseva E.V. Molecular genetic deviations and obstetric pathology.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020;1: 26-32. (In Russian).
https://dx.doi.org/10.18565/aig.2020.1. 26-32