Placental mitochondria in health and in preeclampsia
Objective. To analyze the data available in modern scientific literature on the relationship between preeclampsia and the mitochondrial reticulum.Vishnyakova P.A., Kan N.E., Khodzhaeva Z.S., Vysokikh M.Yu.
Materials and methods. The review included the data available in international peer-reviewed databases. Both works of pioneers in this area and contemporary publications on the topic in question were considered.
Results. The paper describes the basic mechanisms of mitochondrial involvement in the development of preeclampsia, such as cell redox reaction imbalance, apoptotic death, mitochondrial DNA mutations, and structural changes in the mitochondrial reticulum.
Conclusion. Oxidative stress observed in maternal preeclampsia results from complex dysfunction in the mitochondrial reticulum that needs to be thoroughly and comprehensively investigated.
Keywords
preeclampsia
mitochondria
oxidative stress
apoptosis
mitochondrial DNA mutations
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Received 09.11.2016
Accepted 11.11.2016
About the Authors
Vishnyakova Polina Alexandrovna, Researcher, Laboratory of Mitochondrial Medicine, Research Center of Obstetrics of Gynecology and Perinatology,Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: p_vishnyakova@oparina4.ru. ORCID: 0000-0001-8650-8240
Kan Natalia Enkynovna, MD, head of Obstetric Observational Department, Research Center of Obstetrics of Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel: +79262208655. E-mail: kan-med@mail.ru
Khodzaeva Zulfiya Sagdullaevna, MD, professor, senior researcher, Research Center of Obstetrics of Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: z_khodzhaeva@mail.ru
Vyoskikh Mikhail, Candidate of Biological Sciences, Head of the Laboratory of Mitochondrial Medicine, Research Center of Obstetrics of Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: m_vysokikh@oparina4.ru
For citations: Vishnyakova P.A., Kan N.E., Khodzhaeva Z.S.,
Vysokikh M.Yu. Placental mitochondria in health and in preeclampsia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (5): 5-8. (in Russian)
http://dx.doi.org/10.18565/aig.2017.5.5-8
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