Small non-coding RNAs and their potential role in assessing the fertility of a married couple in assisted reproductive technology programs

Shamina M.A., Timofeeva A.V., Kalinina E.A.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow
The authors carried out a systematic analysis of scientific data on the impact of small non-coding RNAs on gametogenesis, embryogenesis, and outcomes of in vitro fertilization programs. Despite the fact that there is a rapid development of assisted reproductive technologies, the rate of successful embryo implantations in the uterine cavity is still at a fairly low level. Therefore, at the moment, scientists are actively searching for the ideal biomarker that determines the quality of gametes and their potential in the formation of a high-quality embryo with the further development of physiological pregnancy. An analysis of the data available in the literature has led to the conclusion that the investigation of small non-coding RNAs with the aim of assessing the fertility of a married couple is extremely promising, relevant, and in tune with the times and will be able to increase the effectiveness of in vitro fertilization programs.

Keywords

assisted reproductive technologies
infertility
in vitro fertilization
embryo implantation
non-coding RNAs
ncRNAs
microRNAs
miRNAs
piviRNAs
piRNAs
endogenous small interfering RNAs
endo-siRNAs
mRNAs
follicular fluid
seminal plasma
spermatozoa
culture medium
blastocyst
pregnancy

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Received 19.06.2019

Accepted 21.06.2019

About the Authors

Maria A. Shamina, student at the Department of Reproductive Health named after professor Leonov Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. Tel. +79160966090 E-mail: mariashamina@mail.ru
117997, Russia, Moscow, Ac. Oparina 4.
Angelika V. Timofeeva, PhD (bio. sci.), Chief of the Laboratory of Applied Transcriptomics at the Department of Systems Biology in Reproduction Kulakov
National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. Tel. +7(495) 438-13-41 E-mail avtimofeeva28@gmail.com
117997, Russia, Moscow, Ac. Oparina 4.
Elena A. Kalinina, MD, Professor, Chief of the Department of Reproductive Health named after professor Leonov Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. Tel.: +7(495) 438-13-41 E-mail: e_kalinina@oparina4.ru
117997, Russia, Moscow, Ac. Oparina 4.

For citations: Shamina M.A., Timofeeva A.V., Kalinina E.A. Small non-coding RNAs and their potential role in assessing the fertility of a married couple in assisted reproductive technology programs.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 11: 33-9.(In Russian).
https://dx.doi.org/10.18565/aig.2019.11.33-39

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