Treatment for diffuse benign breast diseases

Kravchenko E.N., Naboka M.V.

Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia
Timely treatment for benign breast dysplasia (BBD) should be considered as a cancer prevention measure. Objective: To evaluate the efficiency of BBD treatment with the non-hormonal herbal remedy indole carbinol (Indinol Forto). Materials and methods: A total of 150 women aged 30–49 years were comprehensively examined using breast examination and sonography and mammography. The patients were divided into 2 groups. A study group consisted of 75 women with BBD: with benign changes (according to Breast Imaging-Reporting and Data System 2 (BI-RADS 2), manifested as small cysts (up to 10 mm), as well as duct ectasias concurrent with cyclical mastalgias. All the patients were prescribed combination treatment, including concomitant measures. The study group women took indole carbinol-based drugs to treat BBD. A comparison group included 75 women with benign changes (BI-RADS 2), who refused drug treatment for various reasons. Results: Minor mammographic density was noted in 69.3% of the study group patients and in 34.7% of the comparison group (p<0.001); moderate one was seen in 26.6 and 42.7%, respectively (p=0.040). Severe mammographic density was determined in 2.7% of cases in the study group and in 13.3% of those in the comparison group (p=0.017); pronounced one was observed in 1.3% and 9.3% in these groups, respectively (p=0.030). Conclusion: Indinol Forto is shown to be highly effective in treating BBD. Combined with concomitant measures, 6-month therapy with this drug substantially reduces mammographic density. The drug is well tolerated and has no adverse side effects. It can be recommended for widespread use as a first-line drug in women with increased breast density. Authors’ contributions: Kravchenko E.N. – the concept and design of the investigation, analysis of the findings, writing the text, approval of the final version of the article; Naboka M.V. – material collection and processing, analysis and interpretation of these treatment results, writing the text. Conflicts of interest: The authors declare that there are no conflicts of interest. Funding: The investigation has not been sponsored. Patient Consent for Publication: All patients provided informed consent for the publication of their data. Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator. For citation: Kravchenko E.N., Naboka M.V. Treatment for diffuse benign breast diseases. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (2): 140-145 (in Russian)


benign breast dysplasia
indinol carbinol
Indinol Forto


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Received 31.01.2023

Accepted 06.02.2023

About the Authors

Elena N. Kravchenko, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology No. 1, Omsk State Medical University, Ministry of Health of Russia, +7(3812)23-02-93, +7(913)620-81-62,, 644043, Russia, Omsk, Lenin str., 12.
Maxim V. Naboka, Assistant, Department of Oncology, Radiation Therapy, Omsk State Medical University, Ministry of Health of Russia, +7(3812)60-17-46, +7(913)976-16-64,, 644099, Russia, Omsk, Lenin str., 12.

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